Evidence map›Paper›PMID 36421242›Full record

ArticleAntibiotics (Basel, Switzerland)2022

Metabolism Profile of Mequindox in Sea Cucumbers In Vivo Using LC-HRMS.

Xin Mao, Xiaozhen Zhou, Jun He, Gongzhen Liu, Huihui Liu, Han Zhao, Pengjie Luo, Yongning Wu, Yanshen Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Xin MaoDepartment of Marine Product Quality and Safety Inspection Key Laboratory, Yantai University, Yantai 264005, China.ORCID 0000-0001-5220-5292
Xiaozhen ZhouDepartment of Marine Product Quality and Safety Inspection Key Laboratory, Yantai University, Yantai 264005, China.
Jun HeDepartment of Marine Product Quality and Safety Inspection Key Laboratory, Yantai University, Yantai 264005, China.
Gongzhen LiuCollege of Agriculture and Forestry, Linyi University, Linyi 276000, China.
Huihui LiuShandong Marine Resource and Environment Research Institute, Yantai 264006, China.
Han ZhaoDepartment of Marine Product Quality and Safety Inspection Key Laboratory, Yantai University, Yantai 264005, China.
Pengjie LuoNHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100017, China.
Yongning WuNHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100017, China.ORCID 0000-0001-6430-1302
Yanshen LiDepartment of Marine Product Quality and Safety Inspection Key Laboratory, Yantai University, Yantai 264005, China.ORCID 0000-0002-6048-9237
Yantai University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNLinyi University · CNShandong Marine Resource and Environment Research Institute · CN

Funding

National Natural Science Foundation of China 22193064Preparation and revision of veterinary drug residue standards in China SCB-21029
6 · The paper itself

Abstract

In this work, the metabolism behavior of mequindox (MEQ) in sea cucumber in vivo was investigated using LC-HRMS. In total, nine metabolites were detected and identified as well as the precursor in sea cucumber tissues. The metabolic pathways of MEQ in sea cucumber mainly include hydrogenation reduction, deoxidation, carboxylation, deacetylation, and combinations thereof. The most predominant metabolites of MEQ in sea cucumber are 2-iso-BDMEQ and 2-iso-1-DMEQ, with deoxidation and carbonyl reduction as major metabolic pathways. In particular, this work first reported 3-methyl-2-quinoxalinecarboxylic acid (MQCA) as a metabolite of MEQ, and carboxylation is a major metabolic pathway of MEQ in sea cucumber. This work revealed that the metabolism of MEQ in marine animals is different from that in land animals. The metabolism results in this work could facilitate the accurate risk assessment of MEQ in sea cucumber and related marine foods.

Indexed as

carbonyl reductiondeoxidationmequindoxmetabolic pathwaymetabolitessea cucumbers

Identifiers

PMID36421242
PMCPMC9686589
OpenAlexW4309005719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.