Evidence map›Paper›PMID 36421126›Full record

ArticleBiosensors2022

Spatial-Division Multiplexing Approach for Simultaneous Detection of Fiber-Optic Ball Resonator Sensors: Applications for Refractometers and Biosensors.

Madina Shaimerdenova, Takhmina Ayupova, Aliya Bekmurzayeva, Marzhan Sypabekova, Zhannat Ashikbayeva, Daniele Tosi

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Madina ShaimerdenovaSchool of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana 010000, Kazakhstan.
Takhmina AyupovaSchool of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana 010000, Kazakhstan.
Aliya BekmurzayevaSchool of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana 010000, Kazakhstan.ORCID 0000-0002-2780-1006
Marzhan SypabekovaSchool of Engineering and Computer Science, Baylor University, Waco, TX 76798, USA.ORCID 0000-0002-6423-3781
Zhannat AshikbayevaSchool of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana 010000, Kazakhstan.ORCID 0000-0001-9057-5876
Daniele TosiSchool of Engineering and Digital Sciences, Nazarbayev University, 53 Kabanbay Batyr, Astana 010000, Kazakhstan.ORCID 0000-0002-6500-4964
Nazarbayev University · KZBaylor University · USUniversity of Illinois Urbana-Champaign · US

Funding

FDA HHS R01 FD003908Nazarbayev University 091019CRP2117Nazarbayev University 240919FD3908
6 · The paper itself

Abstract

Fiber-optic ball resonators are an attractive technology for refractive index (RI) sensing and optical biosensing, as they have good sensitivity and allow for a rapid and repeatable manufacturing process. An important feature for modern biosensing devices is the multiplexing capacity, which allows for interrogating multiple sensors (potentially, with different functionalization methods) simultaneously, by a single analyzer. In this work, we report a multiplexing method for ball resonators, which is based on a spatial-division multiplexing approach. The method is validated on four ball resonator devices, experimentally evaluating both the cross-talk and the spectral shape influence of one sensor on another. We show that the multiplexing approach is highly efficient and that a sensing network with an arbitrary number of ball resonators can be designed with reasonable penalties for the sensing capabilities. Furthermore, we validate this concept in a four-sensor multiplexing configuration, for the simultaneous detection of two different cancer biomarkers across a widespread range of concentrations.

Indexed as

Biosensing TechniquesRefractometryFiber Optic TechnologyOptical Fibersball resonatorsbiosensors multiplexingcancer biomarkersfiber-tip sensorsmultiplexingoptical-fiber sensorsrefractive index sensorsspatial-division multiplexing

Identifiers

PMID36421126
PMCPMC9688048
OpenAlexW4308971975

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.