Evidence map›Paper›PMID 36421078›Full record

ArticleeLife2022

Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes.

Yi Feng, Rafik Neme, Leslie Y Beh, Xiao Chen, Jasper Braun, Michael W Lu, Laura F Landweber

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. A PIWI protein-dependent DNA N6-adenine methylation pathway inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Nuclear dualism without extensive DNA elimination in the ciliateProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. SDRAP for annotating scrambled or rearranged genomes.NAR genomics and bioinformatics · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yi FengDepartments of Biochemistry and Molecular Biophysics and Biological Sciences, Columbia University, New York, United States.ORCID 0000-0002-2393-1700
Rafik NemeDepartments of Biochemistry and Molecular Biophysics and Biological Sciences, Columbia University, New York, United States.ORCID 0000-0001-8462-5291
Leslie Y BehDepartments of Biochemistry and Molecular Biophysics and Biological Sciences, Columbia University, New York, United States.
Xiao ChenPacific Biosciences, Menlo Park, United States.ORCID 0000-0002-1432-268X
Jasper BraunDepartment of Mathematics and Statistics, University of South Florida, Tampa, United States.ORCID 0000-0003-1250-4399
Michael W LuDepartments of Biochemistry and Molecular Biophysics and Biological Sciences, Columbia University, New York, United States.ORCID 0000-0002-4926-8839
Laura F LandweberDepartments of Biochemistry and Molecular Biophysics and Biological Sciences, Columbia University, New York, United States.ORCID 0000-0002-7030-8540
Columbia University · USPacific Biosciences (United States) · USUniversidad del Norte · MXUniversity of South Florida · US

Funding

Understanding Complex Genome Editing and RNA Biology in OxytrichaR35GM122555 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAURA F LANDWEBER · 2017 to 2026
$7.9M
NIGMS NIH HHS R35 GM122555
6 · The paper itself

Abstract

Ciliates are microbial eukaryotes that undergo extensive programmed genome rearrangement, a natural genome editing process that converts long germline chromosomes into smaller gene-rich somatic chromosomes. Three well-studied ciliates include

Indexed as

ChromosomesGene RearrangementDNA, ProtozoanGenomeGenomicsDNA, Protozoancomparative genomicsEuploteseuplotes woodruffievolutionary biologygeneticsgenome rearrangementgenomicsoxytricha trifallaxOxytricha trifallaxscrambled genetetmemenatransposable elements

Identifiers

PMID36421078
PMCPMC9797194
OpenAlexW4309862268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.