Evidence map›Paper›PMID 36421012›Full record

ArticleCancer reports (Hoboken, N.J.)2023

Epstein-Barr virus detection in endoscopic submucosal dissection-proven early gastric cancer with mixed-type histology.

Hideo Yanai, Daisuke Chihara, Megumi Harano, Eiki Sakaguchi, Seiji Kaino, Tomoyuki Murakami, Jun Nishikawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hideo YanaiDepartment of Clinical Research, National Hospital Organization Kanmon Medical Canter, Shimonoseki, Japan.ORCID 0000-0002-4374-0792
Daisuke ChiharaDepartment of Gastroenterology & Hepatology, Narional Hospital Organization Kanmon Medical Center, Shimonoseki, Japan.
Megumi HaranoDepartment of Gastroenterology & Hepatology, Narional Hospital Organization Kanmon Medical Center, Shimonoseki, Japan.
Eiki SakaguchiDepartment of Gastroenterology & Hepatology, Narional Hospital Organization Kanmon Medical Center, Shimonoseki, Japan.
Seiji KainoDepartment of Gastroenterology & Hepatology, Narional Hospital Organization Kanmon Medical Center, Shimonoseki, Japan.
Tomoyuki MurakamiDepartment of Pathology, National Hospital Organization Kanmon Medical Center, Shimonoseki, Japan.
Jun NishikawaDepartment of Laboratory Science, Yamaguchi University Graduate School of Medicine, Ube, Japan.
Shimonoseki City Hospital · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsEarly gastric cancer (EGC) with mixed-type histology is a significant risk factor for additional surgery after endoscopic submucosal dissection (ESD). On the other hand, Epstein-Barr virus-associated gastric cancer (EBVaGC) with mixed-type histology is a favorable risk factor with regard to lymph node metastasis.

methodsWe performed EBV detection in 13 ESD-proven lesions in 13 cases of early gastric cancer with mixed-type histology using EBV-encoded small RNA1 in situ hybridization (EBER1 ISH).

resultsEBVaGC was diagnosed in only one (7.7%) of the tested lesions. That EBVaGC patient underwent surgery and there was no residual lesion and no lymph metastasis. EBVaGC is not frequent in EGC with mixed-type histology.

conclusionsEBV testing of gastric biopsy specimens seems not to be useful to predict the mixed-type histology results of ESD. However, EBV testing for ESD specimens of EGC with mixed-type histology is expected to be useful for avoiding excessive additional surgery.

Indexed as

Endoscopic Mucosal ResectionEpstein-Barr Virus InfectionsStomach NeoplasmsHerpesvirus 4, HumanHumansRisk Factorsendoscopic submucosal dissectionEpstein-Barr virus-associated gastric cancergastric cancer with mixed-type histology

Identifiers

PMID36421012
PMCPMC10172166
OpenAlexW4309923353

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.