ArticleHuman brain mapping2023
Connectivity between default mode and frontoparietal networks mediates the association between global amyloid-β and episodic memory.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Brain-cognition relationships and treatment outcome in treatment-resistant late-life depression.Nature communications · 2026Article
- Baseline electrophysiology versus oxidative metabolism as traits of inter-network differences in neurometabolic association.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Modelling cognitive outcomes in the UK Biobank: Education, noradrenaline and frontoparietal networks.PloS one · 2026Article
- Amyloid-beta relates to default and attention network connectivity during working memory retrieval.Brain communications · 2026Article
- Shaping the cognitive reserve: the role of lifelong enrichment and education in the Alzheimer's disease continuum.Frontiers in aging neuroscience · 2026Article
- Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Tell me why: A scoping review on the fundamental building blocks of fMRI-based network analysis.NeuroImage. Clinical · 2025Article
- Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology.Brain : a journal of neurology · 2024Article
- A Comparative Analysis of Two Automated Quantification Methods for Regional Cerebral Amyloid Retention: PET-Only and PET-and-MRI-Based Methods.International journal of molecular sciences · 2024Article
- A Shared Multivariate Brain-Behavior Relationship in a Transdiagnostic Sample of Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Identifying discriminative features of brain network for prediction of Alzheimer's disease using graph theory and machine learning.Frontiers in neuroinformatics · 2024Article
- Comparative study on structural and functional brain differences in mild cognitive impairment patients with tinnitus.Frontiers in aging neuroscience · 2024Article
- Connectivity between default mode and frontoparietal networks mediates the association between global amyloid-β and episodic memory.Human brain mapping · 2023Article
- Memory-related default-executive coupling across the lifespan and associations with changes in cognitive control.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Βeta-amyloid (Aβ) is a neurotoxic protein that deposits early in the pathogenesis of preclinical Alzheimer's disease. We aimed to identify network connectivity that may alter the negative effect of Aβ on cognition. Following assessment of memory performance, resting-state fMRI, and mean cortical PET-Aβ, a total of 364 older adults (286 with clinical dementia rating [CDR-0], 59 with CDR-0.5 and 19 with CDR-1, mean age: 74.0 ± 6.4 years) from the OASIS-3 sample were included in the analysis. Across all participants, a partial least squares regression showed that lower connectivity between posterior medial default mode and frontoparietal networks, higher within-default mode, and higher visual-motor connectivity predict better episodic memory. These connectivities partially mediate the effect of Aβ on episodic memory. These results suggest that connectivity strength between the precuneus cortex and the superior frontal gyri may alter the negative effect of Aβ on episodic memory. In contrast, education was associated with different functional connectivity patterns. In conclusion, functional characteristics of specific brain networks may help identify amyloid-positive individuals with a higher likelihood of memory decline, with implications for AD clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.