ArticleArtificial organs2023
The roles of sub-micron and microscale roughness on shear-driven thrombosis on titanium alloy surfaces.
Article in Artificial organs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The Influence of Micropatterned Surfaces on Platelet Adhesion to Reduce the Risk of Thrombus Formation in Left Ventricular Assist Devices.Annals of biomedical engineering · 2026Article
- In Vitro Degradation Studies of 3D-Printed Thermoplastic Polyurethane for the Design of Vascular Implant.Materials (Basel, Switzerland) · 2025Article
- The Impact of Mechanical Circulatory Support Devices on White Blood Cell Phenotype and Function.Cardiovascular engineering and technology · 2025Review
- Advancing Platelet Research Through Live-Cell Imaging: Challenges, Techniques, and Insights.Sensors (Basel, Switzerland) · 2025Review
- In Vitro and In Silico Characterization of the Aggregation of Thrombi on Textured Ventricular Cannula.Annals of biomedical engineering · 2024Article
- Shear Histories Alter Local Shear Effects on Thrombus Nucleation and Growth.Annals of biomedical engineering · 2024Article
- Characterizing thrombus adhesion strength on common cardiovascular device materials.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundContinuous-flow ventricular assist devices (cfVADs) are implanted in patients with end-stage heart failure to assist with blood circulation. However, VAD implantation is associated with dangerous thrombotic complications. Our goal was to determine the impact of micron and sub-micron scale Ti6Al4V surface roughness on adherent platelet aggregate properties under clinically relevant shear rates.
methodsWe used fluorescence microscopy to visualize platelets in real time as they adhered to Ti6Al4V coupons of varying degrees of roughness, including a smooth control, in microfluidic channels and quantified deposition using an image processing algorithm. We systematically characterized roughness using spatial frequencies to generalize results for more blood-biomaterial contact applications.
resultsWe observed that on the control and sub-micron rough surfaces, at 1000 s
conclusionsThese results demonstrated that at high shear rates, thrombi form regardless of surface topography at the scales applied. At lower shear rates, micron-scale surface features cause thrombus formation, whereas submicron features result in innocuous platelet adhesion. These findings have implications for manufacturing costs and other considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.