Evidence map›Paper›PMID 36420823›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Dual-Color Photoconvertible Fluorescent Probes Based on Directed Photooxidation Induced Conversion for Bioimaging.

Lazare Saladin, Victor Breton, Ophélie Dal Pra, Andrey S Klymchenko, Lydia Danglot, Pascal Didier, Mayeul Collot

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lazare SaladinLaboratoire de Bioimagerie et Pathologies, UMR 7021, CNRS/, Université de Strasbourg, 74 route du Rhin, 67401, Illkirch-Graffenstaden, France.
Victor BretonInstitute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Membrane Traffic in Healthy and Diseased Brain, Université Paris Cité, 102 rue de la santé, 75014, Paris, France.
Ophélie Dal PraLaboratoire de Bioimagerie et Pathologies, UMR 7021, CNRS/, Université de Strasbourg, 74 route du Rhin, 67401, Illkirch-Graffenstaden, France.
Andrey S KlymchenkoLaboratoire de Bioimagerie et Pathologies, UMR 7021, CNRS/, Université de Strasbourg, 74 route du Rhin, 67401, Illkirch-Graffenstaden, France.
Lydia DanglotInstitute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Membrane Traffic in Healthy and Diseased Brain, Université Paris Cité, 102 rue de la santé, 75014, Paris, France.ORCID 0000-0001-6190-6605
Pascal DidierLaboratoire de Bioimagerie et Pathologies, UMR 7021, CNRS/, Université de Strasbourg, 74 route du Rhin, 67401, Illkirch-Graffenstaden, France.
Mayeul CollotLaboratoire de Bioimagerie et Pathologies, UMR 7021, CNRS/, Université de Strasbourg, 74 route du Rhin, 67401, Illkirch-Graffenstaden, France.ORCID 0000-0002-8673-1730
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein present a new concept to produce dual-color photoconvertible probes based on a mechanism called Directed Photooxidation Induced Conversion (DPIC). As a support of this mechanism, styryl-coumarins (SCs) bearing Aromatic Singlet Oxygen Reactive Moieties (ASORMs) like furan and pyrrole have been synthesized. SCs are bright fluorophores, which undergo a hypsochromic conversion upon visible light irradiation due to directed photooxidation of the ASORM that leads to the disruption of conjugation. SC-P, a yellow emitting probe bearing a pyrrole moiety, converts to a stable blue emitting coumarin with a 68 nm shift allowing the photoconversion and tracking of lipid droplet in live cells. This new approach might pave the way to a new generation of photoconvertible dyes for advanced bioimaging applications.

Indexed as

Fluorescent DyesLightCoumarinsPhotochemical ProcessesCoumarinsFluorescent DyesFluorescent ProbesLipid DropletsPhotoconversionPhotooxidationPhotoswitching

Identifiers

PMID36420823
PMCPMC10107923
OpenAlexW4309907217

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.