Evidence map›Paper›PMID 36420595›Full record

ArticleExperimental physiology2023

The effect of proportional assist ventilation on the electrical activity of the human diaphragm during exercise.

Emily A M Gerson, Paolo B Dominelli, Michael G Leahy, Shalaya Kipp, Jordan A Guenette, Bruno Archiza, Andrew William Sheel

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06998927 (Proportional Assist Ventilation Plus and Estimation of Respiratory Effort in Critically Ill Patients During the Transition to Spontaneous Ventilation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06998927 active not recruitingnot on this mapstarted 2024, after this paper: background citation

Proportional Assist Ventilation Plus and Estimation of Respiratory Effort in Critically Ill Patients During the Transition to Spontaneous Ventilation: A Prospective Cohort Study

TypeobservationalSponsorArgentinian Intensive Care SocietyRan2024 to 2025Enrolled35ConditionsRespiratory Effort, Proportional Assist Ventilation, Work of BreathingArmsApplication of Proportional Assist Ventilation Plus (PAV+) at three support levels (20%, 50%, 70%) to assess ventilator-displayed work of breathing and its correlation with physiologic measures.
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Emily A M GersonSchool of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.
Paolo B DominelliDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0001-5575-4043
Michael G LeahySchool of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-9209-3982
Shalaya KippSchool of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.
Jordan A GuenetteSchool of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-5779-5014
Bruno ArchizaSchool of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.
Andrew William SheelSchool of Kinesiology, The University of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? What is the effect of lowering the normally occurring work of breathing on the electrical activity and pressure generated by the diaphragm during submaximal exercise in healthy humans? What is the main finding and its importance? Ventilatory assist during exercise elicits a proportional lowering of both the work performed by the diaphragm and diaphragm electrical activity. These findings have implications for exercise training studies using proportional assist ventilation to reduce diaphragm work in patients with cardiopulmonary disease. ABSTRACT: We hypothesized that when a proportional assist ventilator (PAV) is applied in order to reduce the pressure generated by the diaphragm, there would be a corresponding reduction in electrical activity of the diaphragm. Healthy participants (five male and four female) completed an incremental cycle exercise test to exhaustion in order to calculate workloads for subsequent trials. On the experimental day, participants performed submaximal cycling, and three levels of assisted ventilation were applied (low, medium and high). Ventilatory parameters, pulmonary pressures and EMG of the diaphragm (EMG

Indexed as

DiaphragmInteractive Ventilatory SupportExerciseFemaleHumansMaleRespirationRespiration, Artificialoesophageal pressurerespiratory mechanicsventilatory assistwork of breathing

Identifiers

PMID36420595
PMCPMC10103863
OpenAlexW4309862229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.