ReviewFish and shellfish immunology reports2021
Advances in aquatic animal RIG-I-like receptors.
Review in Fish and shellfish immunology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Gut microbiome composition and diversity of wild-caught and hatchery-bred milkfish (Chanos chanos) fry.Journal, genetic engineering & biotechnology · 2025Article
- Transcriptomic Responses of Blue Bat StarInternational journal of molecular sciences · 2025Article
- Article
- Effect of a loss of the mda5/ifih1 gene on the antiviral resistance in a Chinook salmon Oncorhynchus tshawytscha cell line.PloS one · 2024Article
- Transcriptionally distinct B cell profiles in systemic immune tissues and peritoneal cavity of Atlantic salmon (Frontiers in immunology · 2024Article
- Transcriptome-wide analyses of early immune responses in lumpfish leukocytes upon stimulation with poly(I:C).Frontiers in immunology · 2023Article
- PRR-Mediated Immune Response and Intestinal Flora Profile in Soybean Meal-Induced Enteritis of Pearl Gentian Groupers,Frontiers in immunology · 2022Article
- Grass Carp Reovirus VP56 Allies VP4, Recruits, Blocks, and Degrades RIG-I to More Effectively Attenuate IFN Responses and Facilitate Viral Evasion.Microbiology spectrum · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) sense microbial-associated molecular patterns (MAMPs) to activate the innate immune responses. RLRs in aquatic animals include RIG-I, MDA5, LGP2, mollusc RIG-I-like and MDA5-like proteins, which exhibit structural and functional diversity. RLRs data from 30 species of aquatic animals were collected for analysis. Not all species contain all the RLR members. RIG-I is absent in the orders of Perciformes, Cichliformes and Pleuronectiformes, and LGP2-like protein is absent in the class of Bivalvia. Due to the differences in species and variants, the homologous proteins have different responses to pathogens. LGP2 works as an immune homeostasis regulator to balance the immune response. The phylogenetic analysis demonstrates RIG-I and mollusc RIG-I-like present in the same evolutionary branch and appear in the early stage. RIG-I is an ancient PRR in innate antiviral immunity. The prototype of antiviral immune system has emerged in aquatic mollusc. Aquatic animal RLRs were analyzed and summarized in terms of structures, functions, and evolutions, which provide the basic information for future researches in RLRs. Base on the diversity of species and RLRs, more and in-depth studies in aquatic animal RLRs should be done.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.