Evidence map›Paper›PMID 36420231›Full record

ReviewCureus2022

Relation Between Familial Mediterranean Fever and QT Markers (QTc, QTd, and QTcd): A Systematic Review and Meta-Analysis.

Karam R Motawea, Amro A El-Sakka, Omneya A Kandil, Nancy Ahmed, Merna Abdelnaem, Bishoy Zaki, Rowan H Elhalag, Joseph Varney, Sarya Swed, Abdulqadir J Nashwan and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Karam R MotaweaMedicine, Alexandria University, Alexandria, EGY.
Amro A El-SakkaMedicine, Suez Canal University, Ismailia, EGY.
Omneya A KandilMedicine, Alexandria University, Alexandria, EGY.
Nancy AhmedMedicine, Alexandria University, Alexandria, EGY.
Merna AbdelnaemMedicine, Alexandria University, Alexandria, EGY.
Bishoy ZakiMedicine, Ain Shams University, Cairo, EGY.
Rowan H ElhalagMedicine, Alexandria University, Alexandria, EGY.
Joseph VarneyMedicine, American University of the Caribbean, School of Medicine, New York City, USA.
Sarya SwedMedicine, Aleppo University, Aleppo, SYR.
Abdulqadir J NashwanNursing, Hamad Medical Corporation, Doha, QAT.
Bisher SawafInternal Medicine, Faculty of Medicine, Syrian Private Unviersity, Damascus, SYR.
Mohamed SeijariMedical Education, Hamad Medical Corporation, Doha, QAT.
Amr FarwatiInternal Medicine, Hamad Medical Corporation, Doha, QAT.
Naim BattikhMedicine, Jr. Hospital of Cook County, Chicago, USA.
Amine RakabInternal Medicine, Weill Cornell Medicine - Qatar, Education City, QAT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to perform a meta-analysis to evaluate the possible association betweenQT markers and familial Mediterranean fever (FMF). PUBMED, Web of Science, OVID, and SCOPUS databases were searched. Inclusion criteria were randomized control trials or observational studies that compared measurement of the QT markers in FMF patients and healthy controls in both males and females without any age restriction or other comorbidities. RevMan software (5.4) was used to perform the analysis. A total of 14 studies with 1,154 individuals were included in the study. The pooled effect estimate showed a statistically significant association between FMF group and prolonged corrected QT (QTc) and QT dispersion (QTd) (MD= 7.06, 95% CI = 2.68 to 11.43, p-value = 0.002) and (MD= 6.08, 95% CI = 0.84 to 11.32, p-value= 0.02), respectively. No statistically significant difference between FMF group and QT interval and corrected QT dispersion (QTcd) (MD= 2.34, 95% CI = -1.21 to 5.89, p-value = 0.20) and (MD= 4.82, 95% CI = -0.57 to 10.20, p-value = 0.08), respectively. Our findings revealed a statistically significant relationship between FMF and extended QTc and QTd. More randomized multicenter trials are required to confirm our findings.

Indexed as

arrhythmiafamilial mediterranean fevermeta-analysisqt markerssystematic review

Identifiers

PMID36420231
PMCPMC9678238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.