Evidence map›Paper›PMID 36420162›Full record

ReviewComputational and structural biotechnology journal2022

Prospective bacterial and fungal sources of hyaluronic acid: A review.

E V Shikina, R A Kovalevsky, A I Shirkovskaya, Ph V Toukach

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Computational and structural biotechnology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Hyaluronic Acid and Its Synthases-Current Knowledge.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Journal of pharmacy & bioallied sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

E V ShikinaN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russian Federation.
R A KovalevskyN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russian Federation.
A I ShirkovskayaN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russian Federation.
Ph V ToukachN.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky prospect 47, 119991 Moscow, Russian Federation.
N.D. Zelinsky Institute of Organic Chemistry · RULomonosov Moscow State University · RUNational Research University Higher School of Economics · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unique biological and rheological properties make hyaluronic acid a sought-after material for medicine and cosmetology. Due to very high purity requirements for hyaluronic acid in medical applications, the profitability of streptococcal fermentation is reduced. Production of hyaluronic acid by recombinant systems is considered a promising alternative. Variations in combinations of expressed genes and fermentation conditions alter the yield and molecular weight of produced hyaluronic acid. This review is devoted to the current state of hyaluronic acid production by recombinant bacterial and fungal organisms.

Indexed as

amyE, α-amylase (B. subtilis)aprE, subtilisin E (B. subtilis)araR, repressor of arabinose operonsATP, adenosine triphosphatecat, acetyl-CoA:CoA transferaseCSDB, Carbohydrate Structure Databasedcas9, dead Cas9 (derived from S. pyogenes)DO, dissolved oxygeneglS, endoglucanase (B. subtilis)epr, minor extracellular protease (B. subtilis)FDA, Food and Drug administrationGAG, glycosaminoglycangalR, HTH-type transcriptional regulator GalR (E. coli)galS, HTH-type transcriptional regulator GalS (E. coli)galU, UTP-glucose-1-phosphate uridylyltransferaseGlc, glucoseGlcpA, glucuronic acidGlcpNAc, N-acetylglucosamineglmM, phosphoglucosamine mutaseglmS, l-glutamine-d-fructose-6-phosphate aminotransferaseglmU, bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (Corynebacterium glutamicum)Gram-positive bacteriaGRAS, generally recognized as safeHA, hyaluronic acidHAS, hyaluronic acid synthaseHW HA, high-molecular weight hyaluronic acidHyaluronic acidHYBID, hyaluronan-binding protein involved in HA depolymerizationkfiD, UDP-glucose 6-dehydrogenaselacA (ganA), β-galactosidase (B. subtilis)ldh, lactate dehydrogenaseLW HA, low-molecular weight hyaluronic acidmazF, endoribonuclease (E. coli)Microbial fermentationMMP-2, matrix metalloproteinase 2mpr, extracellular metalloprotease (B. subtilis)MurNAc, N-acetylmuramic acidMW, molecular weightND, no datanprB, neutral protease B (B. subtilis)nprE, bacillolysin (B. subtilis)pfkA, ATP-dependent 6-phosphofructokinase (E. coli)pgcA, phosphoglucomutasepoxB, pyruvate:quinone oxidoreductasepta-ackA operon, phosphate acetyltransferase and acetate kinaseRecombinant organismRHAMM, receptor for hyaluronic acid mediated motilitysigF, RNA polymerase sigma-F factor (B. subtilis)SNFG, symbol nomenclature for glycansthrC, threonine synthase (B. subtilis)tuaD, UDP-glucose 6-dehydrogenase (1)udgA, UDP-glucose 6-dehydrogenase (2)UDP, uridine 5′-trihydrogen diphosphateUMP, 5′-uridylic acidupp, uracil phosphoribosyltransferase (B. subtilis)UTP, uridine-5′-triphosphatevHMW HA, very-high-molecular weight hyaluronic acidwprA, cell wall associated protease (B. subtilis)xylR, xylose operon repressor (B. megaterium)zwf, glucose-6-phosphate 1-dehydrogenase

Identifiers

PMID36420162
PMCPMC9676211
OpenAlexW4308929748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.