ArticleFrontiers in cell and developmental biology2022
The diversity of trophoblast cells and niches of placenta accreta spectrum disorders revealed by single-cell RNA sequencing.
Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Gene regulation at the early human maternal-fetal interface.Nature reviews. Genetics · 2026Review
- Transcriptomic Analysis ofInternational journal of molecular sciences · 2026Article
- Transcriptomic Analysis ofbioRxiv : the preprint server for biology · 2026Article
- KRT6A Is a Biomarker of PAS Progression and Enhances the Invasive Ability of Trophoblast Cells.Cells · 2026Article
- Integrated metabolomic and transcriptomic analysis identifies enhanced phosphatidylcholine metabolism in placenta accreta spectrum.BMC pregnancy and childbirth · 2026Article
- Single-cell analysis reveals essential lncRNAs regulating human trophoblast lineage differentiation.Life medicine · 2026Article
- The molecular pathogenesis of placenta accreta spectrum disorder and its clinical applications.Archives of gynecology and obstetrics · 2025Review
- Molecular Insights into Human Placentation: From Villous Morphogenesis to Pathological Pathways and Translational Biomarkers.International journal of molecular sciences · 2025Review
- The maternal-fetal interface at single-cell resolution: uncovering the cellular anatomy of the placenta and decidua.American journal of obstetrics and gynecology · 2025Review
- Single-cell and spatial transcriptomics: Discovery of human placental development and disease.FASEB bioAdvances · 2024Review
- Single-cell and spatial transcriptomics reveal alterations in trophoblasts at invasion sites and disturbed myometrial immune microenvironment in placenta accreta spectrum disorders.Biomarker research · 2024Article
- High-throughput mRNA sequencing of human placenta shows sex differences across gestation.Placenta · 2024Article
- The Evolution of Management Strategies for Placenta Accreta Spectrum.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Unraveling the molecular mechanisms driving enhanced invasion capability of extravillous trophoblast cells: a comprehensive review.Journal of assisted reproduction and genetics · 2024Review
- Diagnostic Role of Cell-Free miRNAs in Identifying Placenta Accreta Spectrum during First-Trimester Screening.International journal of molecular sciences · 2024Article
- Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states.Physiological genomics · 2024Article
- Animal models of the placenta accreta spectrum: current status and further perspectives.Frontiers in endocrinology · 2023Review
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Placenta accreta spectrum disorders (PAS) are severe pregnancy complications that occur when extravillous trophoblast cells (EVTs) invade beyond the uterine inner myometrium and are characterized by hypervascularity on prenatal ultrasound and catastrophic postpartum hemorrhage. The potential mechanisms remain incompletely understood. With single-cell RNA-sequencing analysis on the representative invasive parts and the normal part obtained from the same PAS placenta, we profiled the pathological landscape of invasive PAS placenta and deciphered an intensified differentiation pathway from progenitor cytotrophoblasts (CTBs) to EVTs
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