Evidence map›Paper›PMID 36420051›Full record

ArticleMaterials today. Bio2022

Janus electro-microenvironment membrane with surface-selective osteogenesis/gingival healing ability for guided bone regeneration.

Chunhua Lai, Mingwei Cheng, Chengyun Ning, Yiheng He, Zhengnan Zhou, Zhaoyi Yin, Peijun Zhu, Yan Xu, Peng Yu, Shulan Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chunhua LaiCenter of Oral Implantology, Stomatological Hospital Southern Medical University, Guangzhou, 510280, China.
Mingwei ChengCenter of Oral Implantology, Stomatological Hospital Southern Medical University, Guangzhou, 510280, China.
Chengyun NingSchool of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Yiheng HeCenter of Oral Implantology, Stomatological Hospital Southern Medical University, Guangzhou, 510280, China.
Zhengnan ZhouSchool of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Zhaoyi YinSchool of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, China.
Peijun ZhuCenter of Oral Implantology, Stomatological Hospital Southern Medical University, Guangzhou, 510280, China.
Yan XuCenter of Oral Implantology, Stomatological Hospital Southern Medical University, Guangzhou, 510280, China.
Peng YuSchool of Material Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
Shulan XuCenter of Oral Implantology, Stomatological Hospital Southern Medical University, Guangzhou, 510280, China.
Southern Medical University · CNSouth China University of Technology · CNKunming University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guided bone regeneration is widely applied in clinical practice to treat alveolar bone defects. However, the rate of healing of severe alveolar bone defects is slow, and there is a high incidence of soft tissue wound dehiscence. In this study, we propose a barrier membrane with a Janus electro-microenvironment (JEM) to achieve side-selective bone regeneration and soft tissue healing. The JEM membrane was constructed using a polarized polyvinylidene fluoride ferroelectric membrane with different surface potentials on either side. It promoted osteogenic differentiation and bone regeneration on the negatively polarized side (JEM-) and soft tissue regeneration on the positively polarized side (JEM+). Further investigation revealed that the JEM-mediated promotion of bone formation was related to mitochondrial autophagy, as indicated by depolarization of the mitochondrial membrane potential and the expression of LC3, Pink I, and Parkin. Moreover, the gingival healing promoted by JEM+ was related to oxidative phosphorylation in mitochondria, as indicated by the upregulation of mitochondrial complexes I-V and an increase in ATP generation. The design concept of the JEM provides a new avenue for regulating tissue regeneration between different tissue interfaces.

Indexed as

Electric microenvironmentGuided bone regenerationJanus membraneOsteogenicPiezoelectric

Identifiers

PMID36420051
PMCPMC9676210
OpenAlexW4309676972

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.