Evidence map›Paper›PMID 36419875›Full record

ArticleFrontiers in oncology2022

Promoter hypomethylation and overexpression of TSTD1 mediate poor treatment response in breast cancer.

Muhamad Ansar, Le Thi Anh Thu, Chin-Sheng Hung, Chih-Ming Su, Man-Hsu Huang, Li-Min Liao, Yu-Mei Chung, Ruo-Kai Lin

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhamad AnsarPh.D Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei, Taiwan.
Le Thi Anh ThuGraduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Chin-Sheng HungDivision of Breast Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei, Taiwan.
Chih-Ming SuDepartment of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Man-Hsu HuangDepartment of Pathology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Li-Min LiaoDivision of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Yu-Mei ChungMaster Program in Clinical Genomics and Proteomics; Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
Ruo-Kai LinPh.D Program in the Clinical Drug Development of Herbal Medicine, Taipei Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic alterations play a pivotal role in cancer treatment outcomes. Using the methylation array data and The Cancer Genome Atlas (TCGA) dataset, we observed the hypomethylation and upregulation of thiosulfate sulfurtransferase-like domain containing 1 (

Indexed as

breast cancerchemotherapycirculating cell-free DNA (cfDNA)DNA methylationdrug responsehormone therapyhypomethylationTSTD1

Identifiers

PMID36419875
PMCPMC9676938

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.