ArticleOpen access emergency medicine : OAEM2022
Predictive Performance of the NEWS‒Lactate and NEWS Towards Mortality or Need for Critical Care Among Patients with Suspicion of Sepsis in the Emergency Department: A Prospective Observational Study.
Article in Open access emergency medicine : OAEM, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Predictive performance of an extended NEWS model for acute deterioration in general ward inpatients: a retrospective observational study.Journal of Korean biological nursing science · 2026Article
- Clinical utility of biomarkers for outcomes prediction in adults with suspected sepsis presenting to the emergency department: a synthesis of current evidence.Health technology assessment (Winchester, England) · 2026Article
- Early Sepsis Diagnosis as a Global Imperative: The Role of Raman Spectroscopy.Journal of clinical medicine · 2026Review
- External validation of the International Early Warning Score in non-traumatic emergency department patients: a prospective cohort study.BMC emergency medicine · 2025Observational
- Evaluating Sepsis Mortality Predictions from the Emergency Department: A Retrospective Cohort Study Comparing qSOFA, the National Early Warning Score, and the International Early Warning Score.Journal of clinical medicine · 2025Article
- Adjusting EWS scores for altitude above sea level: is it necessary to predict sepsis mortality in the emergency room?International journal of emergency medicine · 2025Article
- Prehospital qSOFA, mSOFA, and NEWS2 performance for sepsis prediction: A prospective, multi-center, cohort study.Frontiers in medicine · 2023Article
- Prognostic accuracy of lactate and procalcitonin in addition to national early warning score in patients with suspected sepsis - A cross-sectional study in a tertiary care center.International journal of critical illness and injury scienceArticle
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2 authors.
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Abstract
Objective: We aimed to evaluate the National Early Warning Score‒Lactate (NEWS‒L) and NEWS to predict 24-hour mortality as the primary outcome. The secondary outcomes were to predict 48-hour, 28-day, and in-hospital mortality rates, and the need for critical care in patient with suspicion of sepsis at the emergency department (ED). Methods: A prospective observational study was performed in patients aged ≥18 years diagnosed with sepsis in the ED from March to November 2021. Area under the receiver operating characteristic curve (AUROC) analyses determined the predictive values of NEWS and NEWS‒L for 24-hour mortality. Results: Ninety-two patients were enrolled (mean age 68 years, 48 [52.2%] males). Three (3.2%) patients died within 24 hours and 34 (36.9%) patients needed critical care during the ED stay. The median (interquartile range) NEWS and NEWS-L results were higher in the 24-hour non-survivors versus survivors: 12 (10.5, 12.5) versus 8 (6, 9) (p = 0.024) and 18.7 (15.2, 19.1) versus 10.6 (8.9, 13) (p = 0.036), respectively. The adjusted odds ratio (aOR) was 1.22 for the primary outcome as the NEWS-L increased by 1 unit without statistical significance (p = 0.228). The aOR values for the secondary outcomes ranged from 1.34 to 1.67 with statistical significance. A NEWS-L of 11 and a NEWS of 12 predicted 24-hour mortality with sensitivities/specificities of 100%/56% and 67%/91%, respectively. The AUROC values of NEWS-L for mortality at 24 hours, 48 hours, 28 days, and in-hospital patients, and the need for critical care were 0.860, 0.905, 0.813, 0.839, and 0.837, respectively. Conclusion: NEWS-L is an accurate predictor for 24-hour mortality in septic patients in the ED. NEWS‒L performed better than NEWS for each outcome. NEWS‒L demonstrated good to excellent performance and was accurate in predicting sepsis related to adverse outcomes.
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