Evidence map›Paper›PMID 36419447›Full record

ReviewPatterns (New York, N.Y.)2022

Modern views of machine learning for precision psychiatry.

Zhe Sage Chen, Prathamesh Param Kulkarni, Isaac R Galatzer-Levy, Benedetta Bigio, Carla Nasca, Yu Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Patterns (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 2 pooled it
16.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.

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  18. A functional system-informed graph neural network framework to quantify interpretable brain dysfunction in ASD.Neural networks : the official journal of the International Neural Network Society · 2026
    Article
  19. Explainability in AI-enabled medical neurotechnology: a scoping review.Journal of neuroengineering and rehabilitation · 2026
    Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Zhe Sage ChenDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Prathamesh Param KulkarniHeadspace Health, San Francisco, CA 94102, USA.
Isaac R Galatzer-LevyDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Benedetta BigioDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Carla NascaDepartment of Psychiatry, New York University Grossman School of Medicine, New York, NY 10016, USA.
Yu ZhangDepartment of Bioengineering, Lehigh University, Bethlehem, PA 18015, USA.
New York University · USLehigh University · USMETA Health · US

Funding

CRNS: An Integrative Study of Hippocampal-Neocortical Memory Coding during Sleep R01MH118928 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, ZHE SAGE, WILSON, MATTHEW A · 2018 to 2022
$1.8M
Cortical Information Integration as a Model for Pain Perception and BehaviorR01NS121776 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHEN, ZHE SAGE, WANG, JING · 2024 to 2025
$1.2M
NIMH NIH HHS R01 MH118928NINDS NIH HHS R01 NS121776
6 · The paper itself

Abstract

In light of the National Institute of Mental Health (NIMH)'s Research Domain Criteria (RDoC), the advent of functional neuroimaging, novel technologies and methods provide new opportunities to develop precise and personalized prognosis and diagnosis of mental disorders. Machine learning (ML) and artificial intelligence (AI) technologies are playing an increasingly critical role in the new era of precision psychiatry. Combining ML/AI with neuromodulation technologies can potentially provide explainable solutions in clinical practice and effective therapeutic treatment. Advanced wearable and mobile technologies also call for the new role of ML/AI for digital phenotyping in mobile mental health. In this review, we provide a comprehensive review of ML methodologies and applications by combining neuroimaging, neuromodulation, and advanced mobile technologies in psychiatry practice. We further review the role of ML in molecular phenotyping and cross-species biomarker identification in precision psychiatry. We also discuss explainable AI (XAI) and neuromodulation in a closed human-in-the-loop manner and highlight the ML potential in multi-media information extraction and multi-modal data fusion. Finally, we discuss conceptual and practical challenges in precision psychiatry and highlight ML opportunities in future research.

Indexed as

AIartificial intelligencecausalitycomputational psychiatrydeep learningdigital phenotypingdigital psychiatryexplainable AImachine learningMLmolecular biomarkermulti-modal data fusionneurobiomarkerneuroimagingneuromodulationprecision psychiatryteletherapyXAI

Identifiers

PMID36419447
PMCPMC9676543
OpenAlexW4308806761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.