Evidence map›Paper›PMID 36419107›Full record

ArticleBMC endocrine disorders2022

The prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on CD8+ density.

Alexander Wilhelm, Isabelle Lemmenmeier, Alexandros Lalos, Alberto Posabella, Venkatesh Kancherla, Salvatore Piscuoglio, Tarik Delko, Markus von Flüe, Kathrin Glatz, Raoul André Droeser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Alexander Wilhelm *Department of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland. alexander.wilhelm@clarunis.ch.ORCID https://orcid.org/0000-0001-9496-0237
Isabelle Lemmenmeier *Department of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland.
Alexandros LalosDepartment of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland.
Alberto PosabellaDepartment of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland.
Venkatesh KancherlaInstitute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Salvatore PiscuoglioInstitute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Tarik DelkoDepartment of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland.
Markus von FlüeDepartment of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland.
Kathrin GlatzInstitute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Raoul André DroeserDepartment of Surgery, Clarunis, St. Clara Hospital and University Hospital Basel, University of Basel, Basel, Postfach, 4002, Switzerland.
University of Basel · CHUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor infiltration with cytotoxic CD8+ T-cells is associated with a favorable outcome in several neoplasms, including thyroid cancer. The chemokine axis CXCR4/SDF-1 correlates with more aggressive tumors, but little is known concerning the prognostic relevance in relation to the tumor immune microenvironment of differentiated thyroid cancer (DTC).

methodsA tissue microarray (TMA) of 37 tumor specimens of primary DTC was analyzed by immunohistochemistry (IHC) for the expression of CD8+, CXCR4, phosphorylated CXCR4 and SDF-1. A survival analysis was performed on a larger collective (n = 456) at RNA level using data from The Cancer Genome Atlas (TCGA) papillary thyroid cancer cohort.

resultsAmong the 37 patients in the TMA-cohort, the density of CD8+ was higher in patients with less advanced primary tumors (median cells/TMA-punch: 12.5 (IQR: 6.5, 12.5) in T1-2 tumors vs. 5 (IQR: 3, 8) in T3-4 tumors, p = 0.05). In the TCGA-cohort, CXCR4 expression was higher in patients with cervical lymph node metastasis compared to N0 or Nx stage (CXCR4

conclusionThese findings suggest that the prognostic significance of CXCR4 and SDF-1 in differentiated thyroid cancer depends on the density of CD8 positive T-lymphocytes. Further studies with larger sample sizes are needed to support our findings and inform future investigations of new treatment and diagnostic options for a more personalized approach for patients with differentiated thyroid cancer.

Indexed as

AdenocarcinomaThyroid NeoplasmsCD8-Positive T-LymphocytesChemokine CXCL12HumansPrognosisReceptors, CXCR4Thyroid Cancer, PapillaryTumor MicroenvironmentChemokine CXCL12CXCR4 protein, humanReceptors, CXCR4CD8ChemokinesCXCR4Differentiated thyroid cancerSDF-1Tumor microenvironment

Identifiers

PMID36419107
PMCPMC9686066
OpenAlexW4309884910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.