ArticleCerebral cortex (New York, N.Y. : 1991)2023
A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Auditory perceptual maps in humans and mice share common structures and predict perceptual decisions in discrimination learning.Communications psychology · 2026Article
- Statistics of cortical representational drift can enable robust readout.PLoS computational biology · 2026Article
- Representational drift without synaptic plasticity.bioRxiv : the preprint server for biology · 2025Article
- Homeostasis of a representational map in the neocortex.Nature neuroscience · 2025Article
- Perceptual and semantic maps in individual humans share structural features that predict creative abilities.Communications psychology · 2025Article
- Topography and Ensemble Activity in the Auditory Cortex of a Mouse Model of Fragile X Syndrome.eNeuro · 2024Article
- Representational maps in the brain: concepts, approaches, and applications.Frontiers in cellular neuroscience · 2024Review
- Representational drift in barrel cortex is receptive field dependent.bioRxiv : the preprint server for biology · 2023Article
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5 authors.
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Abstract
Recent long-term measurements of neuronal activity have revealed that, despite stability in large-scale topographic maps, the tuning properties of individual cortical neurons can undergo substantial reformatting over days. To shed light on this apparent contradiction, we captured the sound response dynamics of auditory cortical neurons using repeated 2-photon calcium imaging in awake mice. We measured sound-evoked responses to a set of pure tone and complex sound stimuli in more than 20,000 auditory cortex neurons over several days. We found that a substantial fraction of neurons dropped in and out of the population response. We modeled these dynamics as a simple discrete-time Markov chain, capturing the continuous changes in responsiveness observed during stable behavioral and environmental conditions. Although only a minority of neurons were driven by the sound stimuli at a given time point, the model predicts that most cells would at least transiently become responsive within 100 days. We observe that, despite single-neuron volatility, the population-level representation of sound frequency was stably maintained, demonstrating the dynamic equilibrium underlying the tonotopic map. Our results show that sensory maps are maintained by shifting subpopulations of neurons "sharing" the job of creating a sensory representation.
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