Observational studyInternational ophthalmology2023
One-year non-comparative observational study to evaluate corneal tomographic, densitometric, and aberrometric features following accelerated corneal cross-linking in progressive keratoconus.
Observational study in International ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Changes in Corneal Densitometry and Relationship to Corneal Topographical Parameters in Accelerated Corneal Crosslinking for the Treatment of Keratoconus.Journal of clinical medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the 12 months' changes in tomographic, densitometric, and aberrometric parameters in keratoconic eyes after accelerated corneal cross-linking (CCL) and classify a densitometric course in different stages of the keratoconus separately (mild, moderate, and severe).
methodsIn a prospective observational study, 67 keratoconic eyes of 67 patients that underwent accelerated epithelium-off corneal cross-linking (9 mW/cm
resultsOne year after treatment, corrected distance visual acuity (CDVA) was improved, and maximum keratometry, thinnest pachymetry, higher order, and total root mean square (RMS) were significantly decreased (p < 0.001). Corneal densitometry values showed a significant elevation 3 months post-surgery compared to baseline and then decreased to baseline values at 1 year. Only the Anterior 0-2 mm zone densitometry at the 3rd month was different between the three groups. RMS at 1 year correlated with Anterior 0-2 mm, Anterior 2-6 mm, total corneal 0-2 mm, and total corneal 2-6 mm densitometry values in the 3rd month. Final CDVA at 12th month follow-up correlated with the Anterior 0-2 mm corneal densitometry in the 3rd month.
conclusionAnterior 0-2 mm zone densitometry at the 3rd-month post-accelerated CCL is different in various stages of keratoconus. Due to the correlation between final aberrometric and peak densitometric values in keratoconic eyes, peak densitometric values can be used as a prognostic factor for the final visual outcomes after accelerated CCL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.