Evidence map›Paper›PMID 36418769›Full record

ArticleMolecular imaging and biology2023

Glucose Infusion Induced Change in Intracellular pH and Its Relationship with Tumor Glycolysis in a C6 Rat Model of Glioblastoma.

Qi Qi, Matthew S Fox, Heeseung Lim, Rebecca Sullivan, Alex Li, Miranda Bellyou, Lise Desjardins, Andrew McClennan, Robert Bartha, Lisa Hoffman and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Qi QiDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Matthew S FoxDepartment of Physics and Astronomy, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Heeseung LimDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Rebecca SullivanMolecular Imaging Program, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Alex LiRobarts Research Institute, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Miranda BellyouRobarts Research Institute, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Lise DesjardinsImaging Program, Lawson Health Research Institute, London, ON, N6A 4V2, Canada.
Andrew McClennanDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Robert BarthaDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Lisa HoffmanDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Timothy J SchollDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Ting-Yim LeeDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada.
Jonathan D ThiessenDepartment of Medical Biophysics, The University of Western Ontario, London, ON, N6A 3K7, Canada. jthiessen@lawsonimaging.ca.
Western University · CALawson Health Research Institute · CAOntario Institute for Cancer Research · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe reliance on glycolytic metabolism is a hallmark of tumor metabolism. Excess acid and protons are produced, leading to an acidic tumor environment. Therefore, we explored the relationship between the tumor glycolytic metabolism and tissue pH by comparing

methods10

resultsA decrease of 0.14 in pH

conclusionAACID detected the changes in pH

Indexed as

Brain NeoplasmsGlioblastomaAnimalsFluorodeoxyglucose F18GlucoseGlycolysisHydrogen-Ion ConcentrationMagnetic Resonance ImagingMalePyruvatesRatsRats, WistarFluorodeoxyglucose F18GlucosePyruvatesGlucose solutionTissue pHTumor glycolytic metabolism

Identifiers

PMID36418769
OpenAlexW4309924977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.