Evidence map›Paper›PMID 36418733›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Neonatal Behavioral Screen for Mouse Models of Neurodevelopmental Disorders.

Kathryn M Harper, Viktoriya D Nikolova, Monika E Conrad, Sheryl S Moy

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kathryn M HarperDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Viktoriya D NikolovaDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Monika E ConradDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sheryl S MoyDepartment of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. sheryl_moy@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
NICHD NIH HHS P50 HD103573
6 · The paper itself

Abstract

Behavioral phenotyping approaches for neonatal mice are important for investigating early alterations in brain development and function, relevant to neurodevelopmental disorders in humans. This chapter describes a behavioral screen that can provide an overall profile of function across the neonatal and preweaning period while also minimizing pup stress and disturbance of the maternal environment. Testing begins when mice are between 6 and 8 days in age, with additional evaluations at discrete time points until postnatal day (PD) 20-21, using tests for negative geotaxis, surface righting reflex, activity in an open field, acoustic startle responses and sensorimotor gating, and limb clasp.

Indexed as

Neurodevelopmental DisordersReflex, StartleAnimalsDisease Models, AnimalExtremitiesHumansInfant, NewbornMiceNeonatal ScreeningNegative geotaxisPivotingPrepulse inhibitionReaction timeRearingRighting reflex

Identifiers

PMID36418733
OpenAlexW4310088496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.