Evidence map›Paper›PMID 36418707›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Methacrylated Gelatin as an On-Demand Injectable Vehicle for Drug Delivery in Dentistry.

W Benton Swanson, Abdel Hameed Mahmoud, Seth Woodbury, Marco C Bottino

Open access · greenAbstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Bilayer gelatin-methacryloyl scaffold for pulp inflammation suppression and dentin-like tissue regeneration.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

W Benton SwansonDepartment of Biologic and Materials Science and Division of Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Abdel Hameed MahmoudDepartment of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Seth WoodburyDepartment of Biologic and Materials Science and Division of Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
Marco C BottinoDepartment of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA. mbottino@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Personalized Strategies for Periodontal Tissue Regeneration - A Converged Biofabrication ApproachR01DE031476 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marco C Bottino · 2022 to 2026
$2.6M
NOVEL THERAPEUTICS TO TREAT NECROTIC TEETH: THE COMBINATORIAL EFFECT OF A 3D DRUG DELIVERY SYSTEM AND SPATIALLY DESIGNED STEM CELL NICHESR01DE026578 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOTTINO, MARCO C · 2017 to 2021
$1.7M
Exosome-mediated Craniofacial Bone Tissue Engineering by Controlled ReleaseF30DE029359 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, WILLIAM BENTON · 2020 to 2024
$231k
NIDCR NIH HHS F30 DE029359NIDCR NIH HHS R01 DE026578NIDCR NIH HHS R01 DE031476
6 · The paper itself

Abstract

Gelatin methacrylate (GelMA) is a biodegradable and biocompatible engineered material with significant promise for its applications in tissue engineering, drug delivery, and 3D bioprinting applications. Gelatin is functionalized with terminal methacrylate groups which allow for its photoinducible crosslinking, and thereby tunable properties. Photocrosslinking of GelMA solution in situ allows for fabrication of hydrogels to fit patient-specific defects. Given its favorable biologic properties, GelMA may be used as a carrier for bioactive substances necessary to induce regenerative phenotypes or augment healing, such as growth factors and biotherapeutics. Gelatin is cleaved by cell-secreted enzymes such that its degradation, and subsequently release of bioactive substances, is well-matched to tissue regeneration processes. GelMA may be mixed with a wide array of additives to enhance and improve the specificity of its biologic activity. Here, we present two protocols for novel fabrications and their uses as clinically relevant drug delivery systems. GelMA hydrogels provides a versatile platform for the development of injectable drug delivery therapeutics for broad applications in regenerative dental medicine.

Indexed as

Biological ProductsGelatinBiocompatible MaterialsDentistryDrug Delivery SystemsHydrogelsMethacrylatesBiocompatible MaterialsBiological ProductsGelatinHydrogelsMethacrylates3D bioprintingBiofabricationDrug deliveryRegenerative medicineScaffoldsTissue engineering

Identifiers

PMID36418707
PMCPMC11019857
OpenAlexW4310088483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.