Evidence map›Paper›PMID 36418664›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2023

Cryoballoon temperature parameters during cryoballoon ablation predict pulmonary vein reconnection and atrial fibrillation recurrence.

Yaacoub Chahine, Tanzina Afroze, Savannah F Bifulco, Fima Macheret, Nashwa Abdulsalam, Patrick M Boyle, Nazem Akoum

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pulsed-field ablation versus cryoballoon ablation in patients with atrial fibrillation: A systematic review, meta-analysis and meta-regression.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Contemporary Trends in Pulsed Field Ablation for Cardiac Arrhythmias.Journal of cardiovascular development and disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yaacoub ChahineDivision of Cardiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2752-220X
Tanzina AfrozeDivision of Cardiology, University of Washington, Seattle, WA, USA.
Savannah F BifulcoDepartment of Bioengineering, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Fima MacheretDivision of Cardiology, University of Washington, Seattle, WA, USA.
Nashwa AbdulsalamDivision of Cardiology, University of Washington, Seattle, WA, USA.
Patrick M BoyleDepartment of Bioengineering, University of Washington, 1959 NE Pacific Street, Seattle, WA, 98195, USA.
Nazem AkoumDivision of Cardiology, University of Washington, Seattle, WA, USA. nakoum@cardiology.washington.edu.
University of Washington · US

Funding

Mechanistic Relationships Between Fibrosis, Fibrillation, and Stroke: Multi-Scale, Multi-Physics SimulationsR01HL158667 · NHLBI · UNIVERSITY OF WASHINGTON · PI Patrick M Boyle · 2022 to 2026
$3.1M
NHLBI NIH HHS R01 HL158667
6 · The paper itself

Abstract

backgroundCryoballoon ablation (CBA) is an established approach for rhythm management of atrial fibrillation (AF). We sought to assess balloon temperature (BT) parameters as predictors of pulmonary vein (PV) reconnection within the index procedure and AF recurrence following CBA.

methodsBT was monitored in 119 AF patients undergoing CBA. PVs were assessed for reconnection during the procedure and patients were followed for arrhythmia recurrence.

resultsPV reconnection was identified in 39 (8.3%) of 471 PVs. BT was significantly colder in the absence of PV reconnection (30 s: - 33.5 °C [- 36; - 30] vs - 29.5 °C [- 35; - 25.5], p = 0.001; 60 s: - 41 °C [- 44; - 37] vs - 36.5 °C [- 42; - 33.5], p < 0.001; nadir: - 47 °C [- 52; - 43] vs - 41.5 °C [- 47; - 38], p < 0.001). PV reconnection was associated with significantly longer time to reach - 15 °C and - 40 °C (14.5 s [11.5-18.5] vs 12 s [10-15.5], p = 0.023; and 75 s [40-95.5] vs 46 s [37-66.75], p = 0.005) and shorter rewarming time (5.75 s [4.75-8.5] vs 7 s [6-9], p = 0.012). ROC analysis of these procedural parameters had an AUC = 0.71 in predicting PV reconnection. AF recurrence occurred in 51 (42.8%) patients. Kaplan-Meier analysis showed better arrhythmia-free survival for patients in whom BT decreased below - 40 °C in all PVs and patients who had no early PV reconnections, compared to patients in whom BT below - 40 °C was not achieved in at least one PV (log rank = 6.3, p = 0.012) and patients who had PV reconnections (log rank = 4.1, p = 0.043).

conclusionsSlower BT decline, warmer BT nadir, and faster rewarming time predict early PV reconnection. Absence of early PV reconnections and BT dropping below - 40 °C in all PVs during CBA are associated with lower rates of AF recurrence.

Indexed as

Atrial FibrillationCatheter AblationCryosurgeryPulmonary VeinsHumansRecurrenceTemperatureTreatment OutcomeArrhythmia recurrenceAtrial fibrillationBalloon temperatureCryoballoon ablationPulmonary vein reconnection

Identifiers

PMID36418664
PMCPMC10205917
OpenAlexW4309924732

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.