Evidence map›Paper›PMID 36418623›Full record

ArticleEuropean radiology2023

Free water corrected diffusion tensor imaging discriminates between good and poor outcomes of comatose patients after cardiac arrest.

Hanneke M Keijzer, Marco Duering, Ofer Pasternak, Frederick J A Meijer, Marlous M L H Verhulst, Bart A R Tonino, Michiel J Blans, Cornelia W E Hoedemaekers, Catharina J M Klijn, Jeannette Hofmeijer

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03308305 (Cracking Coma), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03308305 completednot on this map

Cracking Coma: Towards EEG and MRI Based Precision Medicine After Cardiac Arrest

TypeobservationalSponsorRijnstate HospitalRan2018 to 2025Enrolled94ConditionsPost-Anoxic Coma, Postanoxic Enchephalopathie
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Predicting glioblastoma progression using MR diffusion tensor imaging: A systematic review.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Hanneke M KeijzerDepartment of Neurology, Rijnstate Hospital, P.O. box 9555, 6800 TA, Arnhem, The Netherlands. HMKeijzer@rijnstate.nl.ORCID http://orcid.org/0000-0002-9889-1918
Marco DueringInstitute for Stroke and Dementia Research (ISD), University Hospital LMU, 81377, Munich, Munich, Germany.
Ofer PasternakDepartments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Frederick J A MeijerDepartment of Radiology and Nuclear Medicine, Radboud University Medical Centre, 6500 HC, Nijmegen, The Netherlands.
Marlous M L H VerhulstDepartment of Neurology, Rijnstate Hospital, P.O. box 9555, 6800 TA, Arnhem, The Netherlands.
Bart A R ToninoDepartment of Radiology, Rijnstate Hospital, 6800 TA, Arnhem, The Netherlands.
Michiel J BlansDepartment of Intensive Care Medicine, 6800 TA, Rijnstate Hospital, Arnhem, The Netherlands.
Cornelia W E HoedemaekersDepartment of Intensive Care Medicine, Radboud University Medical Centre, 6500 HC, Nijmegen, The Netherlands.
Catharina J M KlijnDepartment of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre, 6500 HC, Nijmegen, The Netherlands.
Jeannette HofmeijerDepartment of Neurology, Rijnstate Hospital, P.O. box 9555, 6800 TA, Arnhem, The Netherlands.
Radboud University Nijmegen · NLRijnstate Hospital · NLBrigham and Women's Hospital · USUniversity of Basel · CH

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
Novel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M
NIBIB NIH HHS P41 EB015902NIMH NIH HHS R01 MH074794ZonMw 015008048
6 · The paper itself

Abstract

objectivesApproximately 50% of comatose patients after cardiac arrest never regain consciousness. Cerebral ischaemia may lead to cytotoxic and/or vasogenic oedema, which can be detected by diffusion tensor imaging (DTI). Here, we evaluate the potential value of free water corrected mean diffusivity (MD) and fractional anisotropy (FA) based on DTI, for the prediction of neurological recovery of comatose patients after cardiac arrest.

methodsA total of 50 patients after cardiac arrest were included in this prospective cohort study in two Dutch hospitals. DTI was obtained 2-4 days after cardiac arrest. Outcome was assessed at 6 months, dichotomised as poor (cerebral performance category 3-5; n = 20) or good (n = 30) neurological outcome. We calculated the whole brain mean MD and FA and compared between patients with good and poor outcomes. In addition, we compared a preliminary prediction model based on clinical parameters with or without the addition of MD and FA.

resultsWe found significant differences between patients with good and poor outcome of mean MD (good: 726 [702-740] × 10

conclusionsFree water-corrected MD and FA discriminate between patients with good and poor outcomes after cardiac arrest and hold the potential to add to multimodal outcome prediction. KEY POINTS: • Whole brain mean MD and FA differ between patients with good and poor outcome after cardiac arrest. • Free water-corrected MD can better discriminate between patients with good and poor outcome than uncorrected MD. • A combination of free water-corrected MD (sensitive to grey matter abnormalities) and FA (sensitive to white matter abnormalities) holds potential to add to the prediction of outcome.

Indexed as

Diffusion Tensor ImagingHeart ArrestAnisotropyBrainComaHumansProspective StudiesWaterWaterBrain edemaBrain imagingBrain ischaemiaCardiac arrestMRI

Identifiers

PMID36418623
PMCPMC9935650
OpenAlexW4309884894

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.