Evidence map›Paper›PMID 36418462›Full record

ReviewNature reviews. Genetics2023

The nexus between RNA-binding proteins and their effectors.

Shiyang He, Eugene Valkov, Sihem Cheloufi, Jernej Murn

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 117 citations in OpenAlex.

  1. Article
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  8. Macrophage PABPC4-SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shiyang HeDepartment of Biochemistry, University of California, Riverside, CA, USA.ORCID 0000-0002-1849-2635
Eugene ValkovRNA Biology Laboratory & Center for Structural Biology, Center for Cancer Research, National Cancer Institute (NCI), Frederick, MD, USA.ORCID 0000-0002-3721-1739
Sihem CheloufiDepartment of Biochemistry, University of California, Riverside, CA, USA. sihem.cheloufi@ucr.edu.ORCID 0000-0002-1726-4796
Jernej MurnDepartment of Biochemistry, University of California, Riverside, CA, USA. jernej.murn@ucr.edu.ORCID 0000-0002-1729-5859
University of California, Riverside · USNational Cancer Institute · US

Funding

Molecular Mechanisms of mRNA Regulation and DecayZIABC011977 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI VALKOV, EUGENE · 2020 to 2025
$8.7M
Investigating the molecular mechanisms of early neuronal morphogenesisR01GM144693 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Jernej Murn · 2022 to 2026
$1.7M
NIGMS NIH HHS R01 GM144693
6 · The paper itself

Abstract

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA molecule, from its production to its destruction. Whereas much has been learned about RNA sequence specificity and general functions of individual RBPs, the ways in which numerous RBPs instruct a much smaller number of effector molecules, that is, the core engines of RNA processing, as to where, when and how to act remain largely speculative. Here, we survey the known modes of communication between RBPs and their effectors with a particular focus on converging RBP-effector interactions and their roles in reducing the complexity of RNA networks. We discern the emerging unifying principles and discuss their utility in our understanding of RBP function, regulation of biological processes and contribution to human disease.

Indexed as

RNARNA Processing, Post-TranscriptionalHumansRNA-Binding ProteinsRNARNA-Binding Proteins

Identifiers

PMID36418462
PMCPMC10714665
OpenAlexW4309890087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.