Evidence map›Paper›PMID 36418426›Full record

ArticleJournal of human hypertension2023

Serum levels of autoantibodies against the angiotensin II type I receptor are not associated with serum dicarbonyl or AGE levels in patients with an aldosterone-producing adenoma.

M Piazza, N M J Hanssen, J L J M Scheijen, M Vd Waarenburg, B Caroccia, T M Seccia, C D A Stehouwer, G P Rossi, C G Schalkwijk

Abstract read
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Article in Journal of human hypertension, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

M PiazzaDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.ORCID 0000-0002-6640-5401
N M J HanssenCardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands.
J L J M ScheijenDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.
M Vd WaarenburgDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.
B CarocciaDepartment of Medicine-DIMED University of Padua, Padua, Italy.
T M SecciaDepartment of Medicine-DIMED University of Padua, Padua, Italy.ORCID 0000-0002-3639-4086
C D A StehouwerDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.
G P RossiDepartment of Medicine-DIMED University of Padua, Padua, Italy.ORCID 0000-0002-7963-0931
C G SchalkwijkDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands. c.schalkwijk@maastrichtuniversity.nl.ORCID 0000-0003-0190-2690
Maastricht University Medical Centre · NLUniversity of Padua · ITMaastricht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with an aldosterone-producing adenoma (APA) carry a higher risk of cardiovascular disease and commonly have high levels of autoantibodies (AT1AA) that may activate the angiotensin II type 1 receptor (AT1R). AT1R activation is linked to an increase of the glucose metabolite methylglyoxal (MGO), a potential precursor of advanced glycation endproducts (AGEs) and driver of vascular inflammation. We investigated whether serum AT1AA levels are associated with serum MGO and AGE levels in APA patients. In a case series of 26 patients with APA we measured levels of dicarbonyls MGO, glyoxal (GO) and 3-deoxyglucosone (3-DG), and dicarbonyl-derived AGEs 5-hydro-5-methylimidazolone (MG-H1), N

Indexed as

AdenomaAutoantibodiesAldosteroneAngiotensin IIChromatography, LiquidGlycation End Products, AdvancedGlyoxalHumansInflammationMagnesium OxidePyruvaldehydeReceptor, Angiotensin, Type 1Tandem Mass SpectrometryAldosteroneAngiotensin IIAutoantibodiesGlycation End Products, AdvancedGlyoxalMagnesium OxidePyruvaldehydeReceptor, Angiotensin, Type 1

Identifiers

PMID36418426
OpenAlexW4309889931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.