ArticleScientific reports2022
Noninvasive stimulation of the ventromedial prefrontal cortex modulates rationality of human decision-making.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy.Nature communications · 2026Article
- Ventromedial prefrontal cortex attenuates the link between physiological heart rate reactions to unfairness and value computations in normative decision making.Social cognitive and affective neuroscience · 2026Article
- Editorial: Exploring the framing effect on maladaptive behaviors: neural mechanisms and applications.Frontiers in behavioral neuroscience · 2026Article
- Article
- Noninvasive ventromedial prefrontal cortex stimulation can enhance and impair affective learning from rewarding and threatening stimuli.Social cognitive and affective neuroscience · 2025Article
- Self-referencing versus other-referencing in gambling: effects of vmPFC stimulation on decision-making and feedback processing.Frontiers in behavioral neuroscience · 2025Article
- Dissociable Roles of the Dorsolateral and Ventromedial Prefrontal Cortex in Human Categorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Aversion to light is associated with impulsivity.Frontiers in psychology · 2024Article
- Excitatory stimulation of the ventromedial prefrontal cortex reduces cognitive gambling biases via improved feedback learning.Scientific reports · 2023Article
- Non-invasive stimulation reveals ventromedial prefrontal cortex function in reward prediction and reward processing.Frontiers in neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The framing-effect is a bias that affects decision-making depending on whether the available options are presented with positive or negative connotations. Even when the outcome of two choices is equivalent, people have a strong tendency to avoid the negatively framed option. The ventromedial prefrontal cortex (vmPFC) is crucial for rational decision-making, and dysfunctions in this region have been linked to cognitive biases, impulsive behavior and gambling addiction. Using a financial decision-making task in combination with magnetoencephalographic neuroimaging, we show that excitatory compared to inhibitory non-invasive transcranial direct current stimulation (tDCS) of the vmPFC reduces framing-effects while improving the assessment of loss-probabilities, ultimately leading to increased overall gains. Behavioral and neural data consistently suggest that this improvement in rational decision-making is predominately due to an attenuation of biases towards negative affect (loss-aversion and risk-aversion). These findings recommend further research towards clinical applications of vmPFC-tDCS as in addictive disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.