Evidence map›Paper›PMID 36418313›Full record

ArticleCell death & disease2022

Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury.

Ke Lu, Si-Yu Shen, Ou-Yang Luo, Yue Lu, Tian-Shu Shi, Jing Wu, Qi Cheng, Hua-Jian Teng, Di Chen, Xiang Lu and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Programmed Cell Death in Liver Fibrosis.Journal of inflammation research · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Ke Lu *Core Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.ORCID 0000-0002-1641-4748
Si-Yu Shen *State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Ou-Yang LuoState Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School, Nanjing, 210046, China.
Yue LuState Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School, Nanjing, 210046, China.
Tian-Shu ShiState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Jing WuCore Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.
Qi ChengState Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School, Nanjing, 210046, China.
Hua-Jian TengState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China.
Di ChenFaculty of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xiang LuDepartment of Geriatrics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China.
Chao-Jun LiKey Laboratory of Model Animal for Disease Study of Ministry of Education, Model Animal Research Center, Nanjing University, Nanjing, 210032, China. licj@nju.edu.cn.ORCID 0000-0001-9474-7321
Qing JiangState Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China. qingj@nju.edu.cn.ORCID 0000-0002-2552-9686
Lei FangState Key Laboratory of Pharmaceutical Biotechnology, Nanjing University Medical School, Nanjing, 210046, China. njfanglei@nju.edu.cn.ORCID 0000-0002-2582-4845
Bin XueCore Laboratory, Sir Run Run Hospital, Nanjing Medical University, Nanjing, 211166, China. xuebin@njmu.edu.cn.ORCID 0000-0002-2713-2156
National Clinical Research Center for Digestive Diseases · CNNanjing Medical University · CNNanjing University · CNChinese Academy of Sciences · CNChina Pharmaceutical University · CNModel Animal Research Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the widely used Carbon tetrachloride (CCl

Indexed as

Liver DiseasesMAP Kinase Signaling SystemAnimalsChromatography, LiquidFibrosisHepatocytesMiceMice, KnockoutNecrosisTandem Mass Spectrometry

Identifiers

PMID36418313
PMCPMC9684557
OpenAlexW4309700401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.