SynthesisCanadian journal of surgery. Journal canadien de chirurgie
Efficacy of cold renal perfusion protection for open complex aortic aneurysm repair: a meta-analysis.
Synthesis in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Renal protection by intermittent cold crystalloid perfusion during thoracoabdominal aortic aneurysm repair.General thoracic and cardiovascular surgery · 2026Article
- Mid-term follow-up of renal artery reimplant in open surgical repair for abdominal aortic aneurysm with a crossed-fused renal ectopia.Journal of vascular surgery cases and innovative techniques · 2025Article
- Acute kidney injury and aorta-related mortality during open surgery of the abdominal aorta with suprarenal clamping using different renal protection strategies.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025Observational
- A Systematic Review of Renal Perfusion in Complex Abdominal Aortic Aneurysm Open Repair.Journal of cardiovascular development and disease · 2024Review
- Comparative study of acute kidney injury in pararenal aortic aneurysm: open surgical versus endovascular repair.Frontiers in surgery · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCold renal perfusion (CRP) with 4°C crystalloid fluids has been described as a method to reduce renal injury during open surgical repair of complex aortic aneurysms (cAAs) (those requiring at least a suprarenal clamp site). We performed a meta-analysis to ascertain whether CRP improves kidney-related outcomes after open surgical cAA repair.
methodsPatients of any age or gender who had undergone open surgical repair of cAAs were included. Primary outcomes were the presence of postoperative kidney injury, the need for dialysis and mortality related to kidney injury. We compared patients who were treated with any intraoperative CRP strategy to a control population without CRP. We used a fixed-effects model to analyze derived odds ratios (ORs) and assess heterogeneity. We performed risk of bias analysis to identify potential confounding elements.
resultsAmong the 935 studies screened, 5 primary articles met the inclusion criteria. Cold renal perfusion significantly reduced postoperative acute kidney injury (OR 0.46 [95% confidence interval 0.32-0.68],
conclusionThis meta-analysis showed reduced postoperative acute kidney injury with the use of CRP during open cAA repair. A prospective randomized controlled trial to perform further subgroup analysis and research the various types of CRP solutions may be warranted to identify further possible benefits.
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