ArticleEmerging infectious diseases2022
Emergence and Evolutionary Response of Vibrio cholerae to Novel Bacteriophage, Democratic Republic of the Congo
Article in Emerging infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Genomic epidemiology reveals geographically structured co-circulation of AFR10 and AFR13Microbial genomics · 2026Article
- Structural basis of multimodal adsorption and infection initiation bybioRxiv : the preprint server for biology · 2026Article
- Evolution of pandemic cholera at its global source.Nature · 2026Article
- CholeraSeq: a comprehensive genomic pipeline for cholera surveillance and near real-time outbreak investigation.Bioinformatics (Oxford, England) · 2026Article
- A colorimetric method for detecting virulent bacteriophage to Vibrio cholerae in fecal and environmental samples.PLoS neglected tropical diseases · 2025Article
- Genomic analysis and antimicrobial resistance ofMicrobial genomics · 2025Article
- Lineage-specific defence systems of pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- West African-South American pandemic Vibrio cholerae encodes multiple distinct phage defence systems.Nature microbiology · 2025Article
- Assembly and performance of a cholera RDT prototype that detects bothJournal of clinical microbiology · 2025Article
- Epidemiologic and Genomic Surveillance of Vibrio cholerae and Effectiveness of Single-Dose Oral Cholera Vaccine, Democratic Republic of the Congo.Emerging infectious diseases · 2025Article
- Effectiveness of a single dose of oral cholera vaccine: findings from epidemiological and genomic surveillance ofmedRxiv : the preprint server for health sciences · 2024Article
- Genomic evolution and rearrangement of CTX-Φ prophage elements inEmerging microbes & infections · 2024Article
- Ancestral Origin and Dissemination Dynamics of Reemerging Toxigenic Vibrio cholerae, Haiti.Emerging infectious diseases · 2023Article
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13 authors.
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Abstract
Cholera causes substantial illness and death in Africa. We analyzed 24 toxigenic Vibrio cholerae O1 strains isolated in 2015-2017 from patients in the Great Lakes region of the Democratic Republic of the Congo. Strains originating in southern Asia appeared to be part of the T10 introduction event in eastern Africa. We identified 2 main strain lineages, most recently a lineage corresponding to sequence type 515, a V. cholerae cluster previously reported in the Lake Kivu region. In 41% of fecal samples from cholera patients, we also identified a novel ICP1 (Bangladesh cholera phage 1) bacteriophage, genetically distinct from ICP1 isolates previously detected in Asia. Bacteriophage resistance occurred in distinct clades along both internal and external branches of the cholera phylogeny. This bacteriophage appears to have served as a major driver for cholera evolution and spread, and its appearance highlights the complex evolutionary dynamic that occurs between predatory phage and bacterial host.
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