ArticleCirculation2022
Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity.
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Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
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26 citing papers in PubMed, 41 citations in OpenAlex.
- T cells in acute and chronic myocarditis: from diagnosis to treatment.European heart journal · 2026Review
- Phenotypes and mechanisms of dysfunctional cardiac T-lymphocytes in dilated cardiomyopathy patients.Journal of molecular and cellular cardiology · 2026Article
- Targeting immunometabolic pathways with AZD1656 alleviates inflammation and metabolic dysfunction in type 2 diabetic cardiomyopathy.Nature cardiovascular research · 2026Article
- Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways.Theranostics · 2026Review
- Pro-Inflammatory c-MetAnnals of neurology · 2026Article
- T cells in cardiovascular disease: solved and unsolved mysteries.Science China. Life sciences · 2026Review
- The Etiology Analysis of Myasthenia Gravis with In-Hospital Mortality in the Neurocritical Care Unit.Neurocritical care · 2025Article
- Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination.Circulation · 2025Article
- CD4International journal of molecular sciences · 2025Article
- FoxO1 Deficiency in Monocytic Myeloid-Derived Suppressor Cells Exacerbates B Cell Dysfunction in Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Anti-inflammatory Therapies for Ischemic Heart Disease.Current cardiology reports · 2025Review
- Analysis of effector/memory regulatory T cells from arrhythmogenic cardiomyopathy patients identified IL-32 as a novel player in ACM pathogenesis.Cell death & disease · 2025Article
- Article
- T cells in cardiac health and disease.The Journal of clinical investigation · 2025Review
- Bioactive Products Targeting C-Met As Potential Antitumour Drugs.Anti-cancer agents in medicinal chemistry · 2025Review
- KLK8/HGF/Met signaling pathway mediates diabetes-associated hippocampal neuroinflammation in male mice.Theranostics · 2025Article
- Peripheral blood memory T cells and follicular helper T cells as potential biomarkers for assessing disease severity and in-hospital outcomes in acute myocardial infarction patients.American journal of translational research · 2025Article
- Review
- Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction.Nature cardiovascular research · 2024Article
- CD8Nature cardiovascular research · 2024Article
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Authors and funding
27 authors at 6 institutions in 6 countries.
Silvia Fanti *William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0003-2505-7102
Edward Stephenson *William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.
Etel Rocha-VieiraWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0001-6908-7237
Alexandros ProtonotariosBarts Heart Centre, Barts Health NHS Trust, St Bartholomew's Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.).ORCID 0000-0001-8595-7212
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0002-1691-9615
Eriomina ShahajWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.
M Paula LonghiWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0003-1854-4594
Vishal S VyasWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0001-7756-1509
Carlene DyerWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0002-2136-8504
Elena PontariniWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0003-0439-0344
Angeliki AsimakiMolecular and Clinical Science Institute, St George's, University of London, UK (A.A., C.B.-B.).ORCID 0000-0001-9886-6870
Carlos Bueno-BetiMolecular and Clinical Science Institute, St George's, University of London, UK (A.A., C.B.-B.).ORCID 0000-0003-4626-1276
Monica De GaspariDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (M.D.G., S.R., C.B.).ORCID 0000-0001-9528-4883
Stefania RizzoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (M.D.G., S.R., C.B.).ORCID 0000-0002-8575-1748
Cristina BassoDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua Medical School, Italy (M.D.G., S.R., C.B.).ORCID 0000-0002-0195-9753
Michele BombardieriWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.
David CoeWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.
Guosu WangWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.
Daniel HardingWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0002-7169-4252
Iain GallagherFaculty of Health Sciences & Sport, University of Stirling, UK (I.G.).ORCID 0000-0002-8630-7235
Egle SolitoWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0001-5279-0049
Perry ElliottBarts Heart Centre, Barts Health NHS Trust, St Bartholomew's Hospital, West Smithfield, London (E. Stephenson, A.P., V.S.V., D.H., P.E., K.S., S.A.M.).ORCID 0000-0003-3383-3984
Stephane HeymansMaastricht University Medical Centre, Cardiovascular Research Institute Maastricht, the Netherlands (S.H., M.S.).ORCID 0000-0001-9477-7803
Maurits SikkingMaastricht University Medical Centre, Cardiovascular Research Institute Maastricht, the Netherlands (S.H., M.S.).ORCID 0000-0001-8165-6631
Konstantinos SavvatisWilliam Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.
Saidi A Mohiddin *William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0002-1031-4084
Federica M Marelli-Berg *William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry (S.F., E. Stephenson, E.R.-V., S.K., E. Shahaj, M.P.L., V.S.V., C.D., E.P., M.B., D.C., G.W., D.H., E. Solito, K.S., S.A.M., F.M.M.-B.), Queen Mary University of London, UK.ORCID 0000-0001-8747-5823
Queen Mary University of London · GBSt Bartholomew's Hospital · GBUniversity of Padua · ITMaastricht University Medical Centre · NLSt George's, University of London · GBUniversity of Stirling · GB
Funding
British Heart Foundation AA/18/5/34222British Heart Foundation CH/15/2/32064British Heart Foundation FS/16/18/31973British Heart Foundation FS/18/82/34024British Heart Foundation FS/CRTF/20/24058British Heart Foundation PG/18/27/33616British Heart Foundation RG/14/2/30616British Heart Foundation RG/20/8/34995Medical Research Council MR/N003063/1
Abstract
backgroundAutoimmunity is increasingly recognized as a key contributing factor in heart muscle diseases. The functional features of cardiac autoimmunity in humans remain undefined because of the challenge of studying immune responses in situ. We previously described a subset of c-mesenchymal epithelial transition factor (c-Met)-expressing (c-Met
methodsIn-depth phenotyping of peripheral blood T cells, including c-Met
resultsWe show that c-Met
conclusionsOur study demonstrates that the detection of circulating c-Met
Indexed as
Autoimmune DiseasesCardiomyopathiesMyocarditisAnimalsAutoimmunityCardiac MyosinsHumansInflammationMemory T CellsMiceMyocardiumCardiac Myosinscardiac myosinscardiomyopathieshearthepatocyte growth factorhumansinflammationmicemyocarditistherapeuticsT-lymphocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.