Evidence map›Paper›PMID 36417884›Full record

ArticleCell reports2022

Fibroblasts repair blood-brain barrier damage and hemorrhagic brain injury via TIMP2.

Lingling Xu, Abhijit Nirwane, Ting Xu, Minkyung Kang, Karan Devasani, Yao Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Oligodendrocyte integrin-β1 regulates blood-brain barrier and remyelination in hemorrhagic brain.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Article
  6. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Laminins and the blood-brain barrier.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. A dispensable role of mural cell-derived laminin-Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lingling XuDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL 33612, USA; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA.
Abhijit NirwaneDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL 33612, USA.
Ting XuDepartment of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA.
Minkyung KangDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL 33612, USA.
Karan DevasaniDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL 33612, USA.
Yao YaoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8, Tampa, FL 33612, USA; Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA 30602, USA. Electronic address: yao7@usf.edu.
University of Georgia · USUniversity of South Florida · US

Funding

Endothelial laminin in blood brain barrier regulationR01HL146574 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2019 to 2023
$1.9M
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationRF1AG065345 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$1.8M
Screening and identification of pericyte-specific and subpopulation-specific markersR21AG064422 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2020 to 2021
$415k
Cell-specific changes of laminin expression in the CNS in Alzheimer’s diseaseR21AG073862 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$411k
NHLBI NIH HHS R01 HL146574NIA NIH HHS R21 AG064422NIA NIH HHS R21 AG073862NIA NIH HHS RF1 AG065345
6 · The paper itself

Abstract

The function of fibroblasts in intracerebral hemorrhage (ICH) remains elusive. By targeting Col1α1, a fibroblast-specific marker, we generate mice with ablated Col1α1

Indexed as

Blood-Brain BarrierBrain InjuriesAnimalsBiological TransportCerebral HemorrhageFibroblastsMiceblood-brain barrierCP: Developmental biologyCP: Molecular biologyfibroblastsintracerebral hemorrhageTIMP2

Identifiers

PMID36417884
PMCPMC9769996
OpenAlexW4309679162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.