Evidence map›Paper›PMID 36417797›Full record

ArticleACS chemical neuroscience2022

Radiochemical Synthesis and Evaluation of 3-[

Yang Sun, Nicolas J Guehl, Yu-Peng Zhou, Kazue Takahashi, Vasily Belov, Maeva Dhaynaut, Sung-Hyun Moon, Georges El Fakhri, Marc D Normandin, Pedro Brugarolas

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Synthesis of KBioorganic & medicinal chemistry letters · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yang SunGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.ORCID 0000-0001-6728-4923
Nicolas J GuehlGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.ORCID 0000-0001-6876-8292
Yu-Peng ZhouGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.ORCID 0000-0001-5085-6737
Kazue TakahashiGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.
Vasily BelovGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.
Maeva DhaynautGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.
Sung-Hyun MoonGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.
Pedro BrugarolasGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts02114, United States.ORCID 0000-0002-7455-2743
Harvard University · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Kira Grogg · 2017 to 2026
$14.8M
Can [18F]3F4AP Detect Brain Demyelination? Evaluation of Novel PET Tracer in Nonhuman Primates and HumansR01NS114066 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BRUGAROLAS, PEDRO · 2020 to 2024
$1.8M
NIBIB NIH HHS P41 EB022544NINDS NIH HHS R01 NS114066
6 · The paper itself

Abstract

Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In demyelinated neurons, the axonal potassium channels K

Indexed as

4-AminopyridineBrainDemyelinating DiseasesKv1.1 Potassium ChannelKv1.2 Potassium ChannelMolecular ImagingRadioactive TracersAnimalsBlood-Brain BarrierPermeabilityPrimatesRats3-methyl-4-aminopyridine4-AminopyridineKv1.1 Potassium ChannelKv1.2 Potassium ChannelRadioactive Tracerscarbon-11demyelinationK+ channelsPETpharmacokineticsStille reaction

Identifiers

PMID36417797
PMCPMC9732819
OpenAlexW4309810296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.