Evidence map›Paper›PMID 36417588›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

ASPS Exhibits Anti-Rheumatic Effects by Reprogramming Gut Microbiota and Increasing Serum γ-Glutamylcysteine Level.

Ang Liu, Min Zhang, Yanglin Wu, Chenhui Zhang, Qin Zhang, Xinlin Su, Xu Zhu, Weidong Shi, Jiangyun Liu, Yang Zhang and 3 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Ang LiuDepartment of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, 215125, China.
Min ZhangDepartment of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Yanglin WuDepartment of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, 215125, China.ORCID 0000-0001-5034-4256
Chenhui ZhangDepartment of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, 215125, China.
Qin ZhangDepartment of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, 215125, China.
Xinlin SuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Xu ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Weidong ShiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Jiangyun LiuCollege of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.
Yang ZhangSchool of Biology and Food Engineering, Changshu Institute of Technology, Changshu, 215500, China.
Cheng HuangDepartment of Orthopaedics, China-Japan Friendship Hospital, Beijing, 100029, China.
Zhaowei YanDepartment of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.ORCID 0000-0003-0226-5638
Jun LinDepartment of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou, 215125, China.ORCID 0000-0002-8094-5826
Soochow University · CNChina-Japan Friendship Hospital · CNSuzhou University of Technology · CNTongji University · CN

Funding

Gusu Health Talents Program GSWS2020023Ministry of Education Industry-University Cooperation Collaborative Education Project 202102242002National Natural Science Foundation of China 81802200National Natural Science Foundation of China 81871789National Natural Science Foundation of China 81902203National Natural Science Foundation of China 82172387Natural Science Foundation of Jiangsu Province BK20180052Scientific Research Project of Jiangsu Provincial Bureau of Traditional Chinese Medicine YB201989Suzhou Science and Technology Bureau SKY2022127
6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is an essential cause of labor loss and disability for people worldwide. Acanthopanax senticosus polysaccharide (ASPS) is one of the most important active components from A. senticosus, which exhibits various pharmacological activities such as antioxidation and immunomodulation. However, no studies have reported the application of ASPS in treating RA. This study aims to investigate the therapeutic effect of ASPS on RA and reveal its underlying mechanism. The potential therapeutic effect of ASPS against RA is initially verified in this study using the collagen-induced arthritis model. Moreover, the protective benefits of ASPS are transmitted through the fecal microbiota and blocked by simultaneous antibiotic cocktail treatment, indicating that gut microbiota may be correlated with ASPS. The 16S rRNA sequencing using feces samples and untargeted UPLC-MS metabolomics using serum samples further reveal that ASPS reprograms the arthritic progression triggered dysbiosis, enhances the expression of γ-glutamylcysteine (GGC) synthetase, and enriches the serum concentration of GGC. Furthermore, metabolites GGC is found to be able to effectively interrupt NLRP3 inflammasome activation via inhibiting ASC nucleation and therefore attenuate inflammatory arthritis. Taken together, this work highlights ASPS's therapeutic potential against RA, which mainly exhibits its effects via modulating gut microbiota and regulating GGC production.

Indexed as

Arthritis, RheumatoidGastrointestinal MicrobiomeChromatography, LiquidDipeptidesHumansRNA, Ribosomal, 16STandem Mass SpectrometryDipeptidesgamma-glutamylcysteineRNA, Ribosomal, 16SAcanthopanax senticosus polysaccharidegut microbiotametabolomicsrheumatoid arthritisγ-glutamylcysteine

Identifiers

PMID36417588
PMCPMC9875676
OpenAlexW4309858949

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.