Evidence map›Paper›PMID 36417558›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Conversion of Polyethylenes into Fungal Secondary Metabolites.

Chris Rabot, Yuhao Chen, Swati Bijlani, Yi-Ming Chiang, C Elizabeth Oakley, Berl R Oakley, Travis J Williams, Clay C C Wang

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Mechanism of OJournal of the American Chemical Society · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. A Broad-Spectrum Catalyst for Aliphatic Polymer Breakdown.Journal of the American Chemical Society · 2025
    Article
  7. Article
  8. Catalytic Upcycling of Polyolefins.Chemical reviews · 2024
    Review
  9. Review
  10. Article
  11. Biological Upcycling of Plastics Waste.Annual review of chemical and biomolecular engineering · 2024
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Conversion of Polyethylenes into Fungal Secondary Metabolites.Angewandte Chemie (International ed. in English) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chris RabotDepartment of Pharmacology & Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA.ORCID 0000-0003-1183-1080
Yuhao ChenDonald P. and Katherine B. Loker Hydrocarbon Institute and Department of Chemistry, University of Southern California, 837 Bloom Walk, Los Angeles, CA 90089, USA.
Swati BijlaniDepartment of Pharmacology & Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA.
Yi-Ming ChiangDepartment of Pharmacology & Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA.
C Elizabeth OakleyDepartment of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.ORCID 0000-0001-7170-4775
Berl R OakleyDepartment of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.ORCID 0000-0002-3046-8240
Travis J WilliamsDonald P. and Katherine B. Loker Hydrocarbon Institute and Department of Chemistry, University of Southern California, 837 Bloom Walk, Los Angeles, CA 90089, USA.
Clay C C WangDepartment of Pharmacology & Pharmaceutical Sciences, University of Southern California, 1985 Zonal Ave, Los Angeles, CA 90033, USA.ORCID 0000-0003-2955-7569
University of Southern California · USUniversity of Kansas · US

Funding

Resistance-gene-guided genome mining for novel antifungal compoundsR21AI156320 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI OAKLEY, BERL RAY · 2021 to 2022
$437k
NIAID NIH HHS R21 AI156320NIH HHS R21 AI156320
6 · The paper itself

Abstract

Waste plastics represent major environmental and economic burdens due to their ubiquity, slow breakdown rates, and inadequacy of current recycling routes. Polyethylenes are particularly problematic, because they lack robust recycling approaches despite being the most abundant plastics in use today. We report a novel chemical and biological approach for the rapid conversion of polyethylenes into structurally complex and pharmacologically active compounds. We present conditions for aerobic, catalytic digestion of polyethylenes collected from post-consumer and oceanic waste streams, creating carboxylic diacids that can then be used as a carbon source by the fungus Aspergillus nidulans. As a proof of principle, we have engineered strains of A. nidulans to synthesize the fungal secondary metabolites asperbenzaldehyde, citreoviridin, and mutilin when grown on these digestion products. This hybrid approach considerably expands the range of products to which polyethylenes can be upcycled.

Indexed as

Aspergillus nidulansPolyethylenesCatalysisPlasticsPlasticsPolyethylenesBiosynthesisCatalysisPolyethylenesSynthetic BiologyUpcycling

Identifiers

PMID36417558
PMCPMC10100090
OpenAlexW4308337968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.