ArticleScience translational medicine2022
Precise genomic editing of pathogenic mutations in
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Geographical and Ethnic Heterogeneity in Genetic Dilated Cardiomyopathies.International journal of molecular sciences · 2026Pooled it
- Therapeutic upregulation of gene expression in inherited cardiomyopathies from current approaches to future directions.Nature cardiovascular research · 2026Review
- RNA splicing and cardiovascular disease: a guide for cardiologists.European heart journal · 2026Review
- Precision modification of heart failure signaling by CRISPR-Cas9 base editing.Journal of molecular and cellular cardiology · 2026Review
- G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K-AKT-mTOR Signal Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Novel Truncating Variant c.1222DupC inCirculation. Genomic and precision medicine · 2026Article
- The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing.Nature reviews. Cardiology · 2026Review
- Cytoplasmic RBM20 granules modulate non-RBM20 target splicing through interactions with other splicing factors.Nucleic acids research · 2026Article
- A primer on prime: A prime editing update from advances to first-in-human trial.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Review
- NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing.Clinical and translational medicine · 2026Article
- CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs.EMBO molecular medicine · 2026Article
- Homozygous SGCB splice-site variant causes isolated dilated cardiomyopathy through sarcoglycan complex destabilization in East Asians.The Journal of clinical investigation · 2026Article
- Adeno-Associated Virus Vector Mediated Gene Therapy: A Promising Approach to Transform Hypertrophic Cardiomyopathy Treatment.Biotechnology journal · 2026Review
- Epidemiology of non-ischaemic dilated cardiomyopathy.Nature reviews. Cardiology · 2026Review
- CAMK2D causes heart failure in mice with RBM20 cardiomyopathy.Nature cardiovascular research · 2026Article
- PLN-L31A/I40A for the treatment of inherited heart disease caused by PLN-R14del mutations.Acta pharmacologica Sinica · 2026Article
- Ablation of PKCα Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure.Circulation research · 2026Article
- Review
- Therapeutic base editing alleviates restrictive cardiomyopathy.Cell reports. Medicine · 2026Article
- Emerging Mechanisms and Therapeutic Strategies in Dilated Cardiomyopathy.Biomedicines · 2026Review
50 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Takahiko NishiyamaDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2352-5606
Yu ZhangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-3384-8887
Miao CuiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Hui LiDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4114-8349
Efrain Sanchez-OrtizDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-9358-1630
John R McAnallyDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-6938-2703
Wei TanDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-6008-3854
Jiwoong KimDepartment of Population and Data Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-0220-9329
Kenian ChenDepartment of Population and Data Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lin XuDepartment of Population and Data Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-5815-4457
Rhonda Bassel-DubyDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-7568-410X
Eric N OlsonDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1151-8262
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US
Funding
Training CoreP50HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, IANNACCONE, SUSAN T · 2020 to 2024
$8.0MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JONATHAN Charles COHEN · 2022 to 2026
$7.4MDeciphering the role of a novel micropeptide in cardiac function and dysfunctionR01HL130253 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2016 to 2023
$4.4MTranscriptional Control of Neonatal Heart RegenerationR01HL157281 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2022 to 2025
$2.2MDissecting the cytoprotective role of NRF1 in heart regeneration and repairR00HL153683 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CUI, MIAO · 2022 to 2024
$747kDissecting the cytoprotective role of NRF1 in heart regeneration and repairK99HL153683 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI CUI, MIAO · 2021 to 2022
$190kNHLBI NIH HHS K99 HL153683NHLBI NIH HHS R00 HL153683NHLBI NIH HHS R01 HL130253NHLBI NIH HHS R01 HL157281NICHD NIH HHS P50 HD087351NIDDK NIH HHS P30 DK127984
Abstract
Mutations in RNA binding motif protein 20 (
Indexed as
Cardiomyopathy, DilatedAnimalsGenomicsHumansMiceMutationMyocytes, CardiacRNA-Binding ProteinsRBM20 protein, mouseRNA-Binding Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.