ArticleEpidemiologia (Basel, Switzerland)2020
Initial Inoculum and the Severity of COVID-19: A Mathematical Modeling Study of the Dose-Response of SARS-CoV-2 Infections.
Article in Epidemiologia (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integrating viral kinetics and population spread in a one health framework to explain variant-specific epidemic dynamics.One health (Amsterdam, Netherlands) · 2026Article
- A Trendline and Predictive Analysis of the First-Wave COVID-19 Infections in Malta.Epidemiologia (Basel, Switzerland) · 2023Article
- Flying under the radar - impact and factors influencing asymptomatic DENV infections.Frontiers in cellular and infection microbiology · 2023Review
- Mathematical modeling to study the impact of immigration on the dynamics of the COVID-19 pandemic: A case study for Venezuela.Spatial and spatio-temporal epidemiology · 2022Article
- Theoretical Explanation for the Rarity of Antibody-Dependent Enhancement of Infection (ADE) in COVID-19.International journal of molecular sciences · 2022Article
- SARS-CoV-2 Droplet and Airborne Transmission Heterogeneity.Journal of clinical medicine · 2022Article
- Treatment of Respiratory Viral Coinfections.Epidemiologia (Basel, Switzerland) · 2022Article
- Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study.Epidemiologia (Basel, Switzerland) · 2022Article
- Mathematical modelling of SARS-CoV-2 infection of human and animal host cells reveals differences in the infection rates and delays in viral particle production by infected cells.Journal of theoretical biology · 2021Article
- Estimation of viral kinetics model parameters in young and aged SARS-CoV-2 infected macaques.Royal Society open science · 2021Article
- Molecular Communication Theoretical Modeling and Analysis of SARS-CoV2 Transmission in Human Respiratory System.IEEE transactions on molecular, biological, and multi-scale communications · 2021Article
- Analysis of Key Factors of a SARS-CoV-2 Vaccination Program: A Mathematical Modeling Approach.Epidemiologia (Basel, Switzerland) · 2021Article
- Current and prospective computational approaches and challenges for developing COVID-19 vaccines.Advanced drug delivery reviews · 2021Review
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2 authors.
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Abstract
SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2) causes a variety of responses in those who contract the virus, ranging from asymptomatic infections to acute respiratory failure and death. While there are likely multiple mechanisms triggering severe disease, one potential cause of severe disease is the size of the initial inoculum. For other respiratory diseases, larger initial doses lead to more severe outcomes. We investigate whether there is a similar link for SARS-CoV-2 infections using the combination of an agent-based model (ABM) and a partial differential equation model (PDM). We use the model to examine the viral time course for different sizes of initial inocula, generating dose-response curves for peak viral load, time of viral peak, viral growth rate, infection duration, and area under the viral titer curve. We find that large initial inocula lead to short infections, but with higher viral titer peaks; and that smaller initial inocula lower the viral titer peak, but make the infection last longer.
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