ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023
A common variant close to the "tripwire" linker region of NLRP1 contributes to severe COVID-19.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- GenoDense-Net: unraveling the genomic puzzle of the global pathogen.Tropical diseases, travel medicine and vaccines · 2025Article
- The role of inflammatory gene polymorphisms in severe COVID-19: a review.Virology journal · 2024Review
- Inflammasome-Related Genetic Polymorphisms as Severity Biomarkers of COVID-19.International journal of molecular sciences · 2024Article
- Stimulation of PSTPIP1 to trigger proinflammatory responses in asymptomatic SARS-CoV-2 infections.Heliyon · 2024Article
- Real-time infectious disease endurance indicator system for scientific decisions using machine learning and rapid data processing.PeerJ. Computer science · 2024Article
- Innate Immune Gene Polymorphisms and COVID-19 Prognosis.Viruses · 2023Article
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Authors and funding
23 authors at 5 institutions in 2 countries.
Funding
Abstract
OBJECTIVE AND
designThe heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome receptors, NLRP1 stands out as a good novel candidate as severity factor for COVID-19 disease.
methodsTo address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B, and IL18 single nucleotide variants (SNVs) in a cohort of 945 COVID-19 patients.
resultsThe NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to COVID-19 severity, which could contribute to the excessive cytokine release reported in severe cases.
conclusionInflammasome genetic background contributes to individual response to SARS-CoV-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.