ArticleeLife2022
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 56 citations in OpenAlex.
- Intrinsic timing, not temporal prediction, underlies ramping dynamics in visual and parietal cortex during passive behavior.Science advances · 2026Article
- Article
- Prefrontal cortex interneurons and their contributions to attention, working memory, and adaptive behavior.Progress in neurobiology · 2026Review
- Roles for somatostatin and parvalbumin interneurons in learning and arousal during trace conditioning.iScience · 2025Article
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
- Selective engagement of prefrontal VIP neurons in reversal learning.Science advances · 2025Article
- Brain region-specific gain modulation of place cells by VIP neurons.Nature communications · 2025Article
- Predictive goal coding by dentate gyrus somatostatin-expressing interneurons in male mice.Nature communications · 2025Article
- Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding.Nature communications · 2025Article
- VIP-to-SST Cell Circuit Motif Shows Differential Short-Term Plasticity across Sensory Areas of Mouse Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Moculus: an immersive virtual reality system for mice incorporating stereo vision.Nature methods · 2025Article
- Neocortical somatostatin neuron diversity in cognition and learning.Trends in neurosciences · 2025Review
- Stress-induced VIPergic activation mediates microbiota/Th17cell-dependent depressive-like behaviors.Brain, behavior, and immunity · 2025Article
- Giant pyramidal neurons of the primary motor cortex express vasoactive intestinal polypeptide (VIP), a known marker of cortical interneurons.Scientific reports · 2024Article
- Article
- Stimulus-specific enhancement in mouse visual cortex requires GABA but not VIP-peptide release from VIP interneurons.Journal of neurophysiology · 2024Article
- Transient enhancement of stimulus-evoked activity in neocortex during sensory learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Top-down modulation of visual cortical stimulus encoding and gamma independent of firing rates.bioRxiv : the preprint server for biology · 2024Article
- Glucagon Increases Retinal Rod Bipolar Cell Inhibition Through a D1 Dopamine Receptor-Dependent Pathway That Is Altered After Lens-Defocus Treatment in Mice.Investigative ophthalmology & visual science · 2024Article
- Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward and punishment are represented in local cortical computations. Previously, we identified a cortical neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, in auditory cortex that is recruited by behavioral reinforcers and mediates disinhibitory control by inhibiting other inhibitory neurons. As the same disinhibitory cortical circuit is present virtually throughout cortex, we wondered whether VIP neurons are likewise recruited by reinforcers throughout cortex. We monitored VIP neural activity in dozens of cortical regions using three-dimensional random access two-photon microscopy and fiber photometry while mice learned an auditory discrimination task. We found that reward and punishment during initial learning produce rapid, cortex-wide activation of most VIP interneurons. This global recruitment mode showed variations in temporal dynamics in individual neurons and across areas. Neither the weak sensory tuning of VIP interneurons in visual cortex nor their arousal state modulation was fully predictive of reinforcer responses. We suggest that the global response mode of cortical VIP interneurons supports a cell-type-specific circuit mechanism by which organism-level information about reinforcers regulates local circuit processing and plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.