ArticleClinical obesity2023
Is adiposity related to repeat measures of blood leukocyte DNA methylation across childhood and adolescence?
Yue Wu, Luke Montrose, Joseph K Kochmanski, Dana C Dolinoy, Martha M Téllez-Rojo, Alejandra Cantoral, Adriana Mercado-García, Karen E Peterson, Jaclyn M Goodrich
Open access · hybridAbstract read
In one paragraphArticle in Clinical obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors at 6 institutions in 3 countries.
Yue WuDepartment of Bioinformatics and Biostatistics, Shanghai Jiao Tong University, Shanghai, China.
Luke MontroseDepartment of Community and Environmental Health, Boise State University, Boise, Idaho, USA.
Joseph K KochmanskiDepartment of Translational Neuroscience, Michigan State University, Grand Rapids, Michigan, USA.
Dana C DolinoyDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Martha M Téllez-RojoCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
Adriana Mercado-GarcíaCenter for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, Mexico.
University of Michigan · USInstituto Nacional de Salud Pública · MXBoise State University · USIbero American University · MXMichigan State University · USShanghai Jiao Tong University · CN
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Karen Eileen Peterson · 2010 to 2026
$20.3MStress, Lead, Iron Deficiency and NeurodevelopmentR01ES013744 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Robert O Wright · 2007 to 2026
$13.4MEnvironmental Epigenomics and Precision Environmental HealthR35ES031686 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2020 to 2026
$6.1MLEAD DOSE BIOMARKERS, REPRODUCTION, AND INFANT OUTCOMESR01ES007821 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 1998 to 2010
$4.7MProject 3: Developmental Exposures and Diet: Epigenetics of Metabolic SyndromeP01ES022844 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEEKER, JOHN D., PADMANABHAN, VASANTHA · 2013 to 2018
$3.9MMetal Mixtures and NeurodevelopmentR01ES014930 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROBERT O · 2006 to 2010
$3.2MProject 1: Prenatal Lead Exposure, Early Childhood Growth, and Sexual MaturationP20ES018171 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PETERSON, KAREN EILEEN · 2010 to 2012
$584kEPA RD834800EPA RD83543601NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIEHS NIH HHS P01 ES022844NIEHS NIH HHS P01 ES02284401NIEHS NIH HHS P20 ES018171NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES007821NIEHS NIH HHS R01 ES013744NIEHS NIH HHS R01 ES014930NIEHS NIH HHS R35 ES031686
6 · The paper itselfAbstract
Epigenetic modifications such as DNA methylation may influence gene expression and phenotypes, including obesity in childhood. The directionality of this relationship is nevertheless unclear, and some evidence suggests that adiposity modifies the epigenome, rather than the other way around. In this pilot study, we utilize data from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) study to examine whether measures of adiposity in childhood and early adolescence are associated with repeated measures of blood leukocyte DNA methylation at LINE-1 repetitive elements and two genes implicated in growth and adiposity: H19 and HSD11B2. Longitudinal epigenetic data were generated from cord blood and blood from follow-up visits in early and late adolescence. We assessed interactions between age and measures of body mass index (BMI) at 5 years of age and weight, BMI and waist circumference in early adolescence to infer whether adiposity deflects age-related DNA methylation changes throughout childhood. Applying linear mixed-effects models, we found an inverse association between measures of childhood BMI (kg/m
Indexed as
AdiposityPediatric ObesityBody Mass IndexDNA MethylationHumansLeukocytesPilot ProjectsbiomarkersDNA methylationepigeneticsobesity
Identifiers
PMID36416295
PMCPMC9991944
OpenAlexW4309765501
What OpenQuestion holds
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LicenceTDM
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