Evidence map›Paper›PMID 36416229›Full record

ArticleAIDS research and human retroviruses2023

Pharmacokinetics, the Immunological Impact, and the Effect on HIV

Lorna Leal, Alberto C Guardo, Luis M Bedoya, Cristina Rodríguez de Miguel, Núria Climent, Cristina Rovira, Manuela Beltrán, Josep Llach, Jose Alcamí, Angela D M Kashuba and 3 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. ADS-J21 is a novel HIV-1 entry inhibitor targeting gp41.Current research in microbial sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Lorna LealDepartment of Infectious Diseases, Hospital Clínic Barcelona, Barcelona, Spain.ORCID 0000-0001-7887-6027
Alberto C GuardoAIDS and HIV Infection Research Group, IDIBAPS, Barcelona, Spain.
Luis M BedoyaAIDS Immunopathogenesis Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Cristina Rodríguez de MiguelEndoscopy Unit, Hospital Clínic Barcelona, CIBERehd, Barcelona, Spain.
Núria ClimentAIDS and HIV Infection Research Group, IDIBAPS, Barcelona, Spain.
Cristina RoviraAIDS and HIV Infection Research Group, IDIBAPS, Barcelona, Spain.
Manuela BeltránAIDS Immunopathogenesis Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Josep LlachEndoscopy Unit, Hospital Clínic Barcelona, CIBERehd, Barcelona, Spain.
Jose AlcamíAIDS Immunopathogenesis Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Angela D M KashubaDivision of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill, Eshelman School of Pharmacy, Chapel Hill, North Carolina, USA.
Jose M GatellFaculty of Medicine, Universitat de Barcelona, Barcelona, Spain.
Montserrat PlanaAIDS and HIV Infection Research Group, IDIBAPS, Barcelona, Spain.
Felipe GarcíaDepartment of Infectious Diseases, Hospital Clínic Barcelona, Barcelona, Spain.
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Clínic de Barcelona · ESInstituto de Salud Carlos III · ESUniversidad Complutense de Madrid · ESUniversity of North Carolina at Chapel Hill · USViiV Healthcare (Spain) · ES

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
NIAID NIH HHS P30 AI050410
6 · The paper itself

Abstract

Most of the studies using the colorectal tissue explants challenge model have been conducted after one single dose and before reaching a steady state. We consider that longer exposure as in 28-day postexposure prophylaxis (PEP) course and in an

Indexed as

Anti-HIV AgentsHIV InfectionsSexual and Gender MinoritiesEmtricitabineHomosexuality, MaleHumansLopinavirMaleMaravirocPost-Exposure ProphylaxisRaltegravir PotassiumRitonavirAnti-HIV AgentsEmtricitabineLopinavirMaravirocRaltegravir PotassiumRitonavirHIVmaravirocpostexposure prophylaxispreventionrectal explants

Identifiers

PMID36416229
PMCPMC10325810
OpenAlexW4309752260

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.