Evidence map›Paper›PMID 36416126›Full record

ArticleStroke2023

Physical Activity Is Inversely Associated With Severe Intracranial Stenosis in Stroke-Free Participants of NOMAS.

Dixon Yang, Minghua Liu, Joshua Z Willey, Farid Khasiyev, Sarah E Tom, Tatjana Rundek, Ying K Cheung, Clinton B Wright, Ralph L Sacco, Mitchell S V Elkind and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Mediterranean-style diet and intracranial large artery stenosis in the Northern Manhattan Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Dixon YangDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (D.Y., M.LL., J.Z.W., S.E.T., M.S.V.E., J.G.).ORCID 0000-0002-7155-8904
Minghua LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (D.Y., M.LL., J.Z.W., S.E.T., M.S.V.E., J.G.).ORCID 0000-0003-3197-6068
Joshua Z WilleyDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (D.Y., M.LL., J.Z.W., S.E.T., M.S.V.E., J.G.).ORCID 0000-0001-5180-2044
Farid KhasiyevDepartment of Neurology, St. Louis University, MO (F.K.).ORCID 0000-0002-3127-0973
Sarah E TomDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (D.Y., M.LL., J.Z.W., S.E.T., M.S.V.E., J.G.).ORCID 0000-0003-0094-5138
Tatjana RundekDepartment of Neurology (T.R., R.L.S.), University of Miami Miller School of Medicine, FL.ORCID 0000-0002-7115-9815
Ying K CheungDepartment of Biostatistics (Y.K.C.), Mailman School of Public Health, Columbia University, New York, NY.ORCID 0000-0001-8530-035X
Clinton B WrightNational Institute of Neurologic Disorders and Stroke, Bethesda, MD (C.B.W.).ORCID 0000-0002-9797-6215
Ralph L SaccoDepartment of Neurology (T.R., R.L.S.), University of Miami Miller School of Medicine, FL.ORCID 0000-0003-4629-684X
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (D.Y., M.LL., J.Z.W., S.E.T., M.S.V.E., J.G.).ORCID 0000-0003-2562-1156
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY (D.Y., M.LL., J.Z.W., S.E.T., M.S.V.E., J.G.).ORCID 0000-0002-2175-8078
Columbia University · USUniversity of Miami · USColumbia University Irving Medical Center · USNational Institute of Neurological Disorders and Stroke · USWashington University in St. Louis · US

Funding

STROKE INCIDENCE AND RISK FACTORS IN A TRI-ETHNIC REGIONR01NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 1993 to 2019
$19.2M
Stroke Incidence and Risk Factors in a Tri-Ethnic RegionR37NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, SACCO, RALPH L. · 2008 to 2014
$12.1M
NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and dementiaR01AG057709 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2018 to 2022
$4.6M
Accelerated non-atherosclerotic brain arterial aging relationship to Alzheimer's diseaseR01AG066162 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2019 to 2023
$3.1M
Vascular Determinants of Dementia and Cognitive Decline in a Tri-Ethnic RegionR56NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, RUNDEK, TATJANA · 2021 to 2021
$537k
NIA NIH HHS R01 AG057709NIA NIH HHS R01 AG066162NINDS NIH HHS R01 NS029993NINDS NIH HHS R37 NS029993NINDS NIH HHS R56 NS029993NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

backgroundAlthough protective in secondary stroke prevention of intracranial arterial stenosis (ICAS), it is uncertain if the benefits of leisure time physical activity (LTPA) extend to asymptomatic ICAS or extracranial carotid stenosis (ECAS). Therefore, we sought to determine LTPA's relationship with ECAS and ICAS in a stroke-free, race-ethnically diverse cohort.

methodsThis cross-sectional study included participants from the magnetic resonance imaging substudy of the Northern Manhattan Study, of whom 1274 had LTPA assessments at enrollment. LTPA was represented continuously as metabolic equivalent score (MET-score) and ordinally as model-based cluster analysis (LTPA-cluster), both based on the same LTPA assessments. We evaluated ECAS sonographically using carotid intima-media thickening and number of carotid plaques. ICAS was assessed with time-of-flight magnetic resonance angiograph and defined as ≥50% or ≥70% stenosis. We applied regression analyses to evaluate the association between LTPA with ECAS and ICAS, adjusting for confounders.

resultsOf 1274 included participants (mean age 71±9 years; 60% women; 65% Hispanic), the mean MET-score was 10±16 and 60% were in a LTPA-cluster with any activity. Among those with carotid ultrasound (n=1234), the mean carotid intima-media thickening was 0.97±0.09 mm, and 56% of participants had at least one carotid plaque identified. Among those with magnetic resonance angiograph (n=1211), 8% had ≥50% ICAS and 5% had ≥70% ICAS. For ICAS, MET-score was associated with ≥70% ICAS (adjusted odds ratio per unit increase in MET-score [95% CI, 0.97 [0.94-0.99]) but not with ECAS measures (carotid intima-media thickening, adjusted β-estimate per unit increase in MET-score [95% CI], 0.002 [-0.003 to 0.006] or number of plaques, adjusted β-estimate [95% CI], 0.0001 [-0.0001 to 0.0003]). Substituting MET-score with LTPA-clusters replicated the association between ≥70% ICAS and LTPA (adjusted odds ratio per each increased LTPA-cluster [95% CI], 0.83 [0.70-0.99]).

conclusionsIn this diverse stroke-free population, we found LTPA most strongly associated with asymptomatic ≥70% ICAS. Given the high-risk nature of ≥70% ICAS, these findings may emphasize the role of LTPA in people at risk for ICAS.

Indexed as

Carotid StenosisNomaStrokeAgedAged, 80 and overConstriction, PathologicCross-Sectional StudiesExerciseFemaleHumansMaleMiddle AgedRisk Factorscarotid intima-media thicknesscarotid stenosisintracranial arterial diseasesmagnetic resonance imagingmetabolic equivalentphysical activity

Identifiers

PMID36416126
PMCPMC9780184
OpenAlexW4309838651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.