Trial reportJournal of biological rhythms2023
Evening Light Intensity and Phase Delay of the Circadian Clock in Early Childhood.
Trial report in Journal of biological rhythms, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07391852 (Circadian Light Exposure Adjustment for Restfulness), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Circadian Light Exposure Adjustment for Restfulness
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Melatonin Use in Young Children: A Systematic Review.JAMA network open · 2026Pooled it
- Considerations and guidelines for photic measurement in field studies of the physiological effects of light.Npj biological timing and sleep · 2026Review
- A step beyond the cage: How infradian and circadian research in mice translates to humans.The Journal of physiology · 2026Article
- Variable Morning Melatonin Profiles Limit Determination of Dim-Light Melatonin Offset in Preschool-Aged Children.Journal of biological rhythms · 2026Article
- Quantifying the biological impacts of nightlights: implications for sleep and circadian health in children.Npj biological timing and sleep · 2026Article
- The Relationship Between Circadian Phase and Sleep Timing in Preschool-Aged Children.Journal of biological rhythms · 2026Article
- Digital Ecosystems, Children, and Adolescents: Technical Report.Pediatrics · 2026Review
- Beyond screen use duration: the role of evening TV-timing on sleep in preschool-aged children.Frontiers in sleep · 2026Article
- Earlier bedtime at 1.5 years is associated with greater height gain at 3 years of age: a nationwide birth cohort study of the Japan environment and children's study.Frontiers in public health · 2026Article
- [Performance of a prompt engineering method for extracting individual risk factors of precocious puberty from electronic medical records].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- The Circadian Response to Evening Light Spectra in Early Childhood: Preliminary Insights.Journal of biological rhythms · 2025Article
- Sleep Across the Lifespan: A Neurobehavioral Perspective.Current sleep medicine reports · 2025Review
- Mapping the physiological changes in sleep regulation across infancy and young childhood.PLoS computational biology · 2024Article
- Nocturnal Smartphone Use Affects Sleep Quality and Cognitive and Physical Performance in Tunisian School-Age Children.European journal of investigation in health, psychology and education · 2024Article
- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- Socioeconomic factors, sleep timing and duration, and amygdala resting-state functional connectivity in children.Frontiers in psychiatry · 2024Article
- Modeling the Effects of Napping and Non-napping Patterns of Light Exposure on the Human Circadian Oscillator.Journal of biological rhythms · 2023Article
- Creating the Cave: Conducting Circadian Science in Early Childhood.Clocks & sleep · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Late sleep timing is prevalent in early childhood and a risk factor for poor behavioral and health outcomes. Sleep timing is influenced by the phase of the circadian clock, with later circadian timing linked to delayed sleep onset in young children. Light is the strongest zeitgeber of circadian timing and, in adults, evening light produces circadian phase delay in an intensity-dependent manner. The intensity-dependent circadian phase-shifting response to evening light in children, however, is currently unknown. In the present study, 33 healthy, good-sleeping children aged 3.0 to 4.9 years (M = 4.14 years, 39% male) completed a 10-day between-subjects protocol. Following 7 days of a stable sleep schedule, an in-home dim-light circadian assessment was performed. Children remained in dim-light across 3 days (55 h), with salivary melatonin collected in regular intervals throughout each evening. Phase-shifting effects of light exposure were determined via changes in the timing of the dim-light melatonin onset (DLMO) prior to (Day 8) and following (Day 10) a light exposure stimulus. On Day 9, children were exposed to a 1 h light stimulus in the hour before their habitual bedtime. Each child was randomly assigned to one intensity between 5 and 5000 lux (4.5-3276 melanopic EDI). Across light intensities, children showed significant circadian phase delays, with an average phase delay of 56.1 min (SD = 33.6 min), and large inter-individual variability. No relationship between light intensity and magnitude of the phase shift was observed. However, a greater percentage of melatonin suppression during the light exposure was associated with a greater phase delay (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.