Evidence map›Paper›PMID 36415644›Full record

ReviewAdvanced pharmaceutical bulletin2022

Inorganic Nanoparticles: Toxic Effects, Mechanisms of Cytotoxicity and Phytochemical Interactions.

Rashid Bhatti, Hadia Shakeel, Kausar Malik, Muhammad Qasim, Mohsin Ahmad Khan, Nadeem Ahmed, Shajia Jabeen

Open access · diamondAbstract readReview
In one paragraph

Review in Advanced pharmaceutical bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Nanoparticles as an Encouraging Therapeutic Approach to Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Review
  13. Using aptamers for targeted delivery of RNA therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rashid BhattiMolecular Medicine Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.ORCID https://orcid.org/0000-0001-7971-5874
Hadia ShakeelMolecular Medicine Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Kausar MalikMolecular Medicine Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Muhammad QasimDepartment of Bioinformatics and Biotechnology, Government College University, Faisalabad, Pakistan.
Mohsin Ahmad KhanDevelopment of Recombinant Biopharmaceuticals Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Nadeem AhmedDevelopment of Recombinant Biopharmaceuticals Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Shajia JabeenMolecular Medicine Lab, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
Centre of Excellence in Molecular Biology · PKGovernment College University, Faisalabad · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the last few decades, nanotechnology has gained many applications in almost all fields of life because of the unique properties of nanoparticles (NPs). Nanotechnology has specially marked its name in the field of medicine. However, NPs toxicity is detrimental to human health and is a prime concern in applied medicine. They can cause insomnia, vertigo, madarosis, epistaxis, hypokalemia, lymphopenia, Alzheimer's and Parkinson's diseases, etc. There is a gap in knowledge regarding the study of the toxicological effects of NPs. Mechanisms that are responsible for this toxicity are not fully understood yet. Phytochemicals have natural therapeutic effects of reducing metal NPs' toxicity by acting as stabilizers and nontoxic reducing agents. However, the interaction between phytochemicals and NPs is remained to be elucidated. This review will provide in-depth knowledge about the various types of inorganic NPs and their associated toxicities, key parameters determining the toxic behaviour of NPs, and the mechanisms behind their cytotoxicity. It also emphasizes the need for further research to understand the interaction between various phytochemicals and NPs for therapeutic purposes.

Indexed as

MedicineNanoparticlesPhytochemicalsTherapeutic effectsToxicity

Identifiers

PMID36415644
PMCPMC9675927
OpenAlexW3205159007

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.