Evidence map›Paper›PMID 36415607›Full record

ArticleInternational journal of clinical and health psychology : IJCHP

Sleep predicts the response to rTMS and CBT in patients with OCD: an open label effectiveness study.

Priya T Gajadien, Tjardo S Postma, Iris van Oostrom, Karel W F Scheepstra, Hanneke van Dijk, Alexander T Sack, Odile A van den Heuvel, Martijn Arns

Open access · goldAbstract read
In one paragraph

Article in International journal of clinical and health psychology : IJCHP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Priya T GajadienUniversiteit van Amsterdam, the Netherlands.
Tjardo S PostmaDepartment of Psychiatry and Department of Anatomy & Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience (Compulsivity, Impulsivity and Attention), Amsterdam, The Netherlands.
Iris van Oostromneurocare clinics, Nijmegen, the Netherlands.
Karel W F ScheepstraAmsterdam UMC, University of Amsterdam, Adult Psychiatry, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, Netherlands.
Hanneke van DijkResearch Institute Brainclinics, Brainclinics Foundation, Nijmegen, the Netherlands.
Alexander T SackFaculty of Psychology and Neuroscience, Maastricht University, the Netherlands.
Odile A van den HeuvelDepartment of Psychiatry and Department of Anatomy & Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience (Compulsivity, Impulsivity and Attention), Amsterdam, The Netherlands.
Martijn ArnsResearch Institute Brainclinics, Brainclinics Foundation, Nijmegen, the Netherlands.
Maastricht University · NLAmsterdam Neuroscience · NLBrainclinics · NLNetherlands Institute for Neuroscience · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although many OCD patients benefit from repetitive transcranial magnetic stimulation (rTMS) as treatment, there is still a large group failing to achieve satisfactory response. Sleep problems have been considered transdiagnostic risk factors for psychiatric disorders, and prior work has shown comorbid sleep problems in OCD to be associated with non-response to rTMS in OCD. We therefore set out to investigate the utility of sleep problems in predicting response to rTMS in treatment resistant OCD. Method: A sample of 61 patients (treated with 1-Hz SMA or sequential 1-Hz SMA+DLPFC rTMS, combined with cognitive behavioral therapy) were included. Sleep disturbances were measured using the PSQI, HSDQ and actigraphy. Treatment response was defined as a decrease of at least 35% in symptom severity as measured with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). Results: 32 of 61 patients (52.5%) responded to rTMS, and trajectories of response were similar for both rTMS protocols. Three PSQI items (Subjective Sleep Quality; Sleep Latency and Daytime Dysfunction) and the HSDQ-insomnia scale were found to predict TMS response. A discriminant model yielded a significant model, with an area under the curve of 0.813. Conclusion: Future replication of these predictors could aid in a more personalized treatment for OCD.

Identifiers

PMID36415607
PMCPMC9672947
OpenAlexW4309103522

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.