ArticleNational science review2022
Bridging oxidase catalysis and oxygen reduction electrocatalysis by model single-atom catalysts.
Article in National science review, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Nanozymes for Energy and Environmental Sustainability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Preparation and biomedical applications of single-metal atom catalysts.Nature protocols · 2026Review
- Multi-enzyme active temperature-sensitive hydrogel with reactive oxygen species scavenging and antimicrobial capacity for diabetic wound repair.Burns & trauma · 2026Article
- Low-spin state design of highly active diatomic catalysts for oxygen reduction reaction.National science review · 2026Article
- Bioinspired Design of Heterogenous Single-Atomic-Site Catalysts for Electrocatalysis and Photocatalysis.Advanced materials (Deerfield Beach, Fla.) · 2025Review
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- ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non-Small Cell Lung Cancer.Exploration (Beijing, China) · 2025Article
- Nanozymes expanding the boundaries of biocatalysis.Nature communications · 2025Review
- Two-dimensional graphene nanomaterials for combined photothermal and chemotherapy-enhanced targeted therapy of breast cancer.Materials today. Bio · 2025Article
- Engineered Nanocatalyst-Enabled Cheolesterol Depletion for Enhanced Tumor Piezocatalytic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly killBioactive materials · 2025Article
- A bioinspired sulfur-Fe-heme nanozyme with selective peroxidase-like activity for enhanced tumor chemotherapy.Nature communications · 2024Article
- Pathologically catalyzed physical coating restores the intestinal barrier for inflammatory bowel disease therapy.Journal of nanobiotechnology · 2023Article
- Single-atom catalysts-based catalytic ROS clearance for efficient psoriasis treatment and relapse prevention via restoring ESR1.Nature communications · 2023Article
- Molecular insights of nanozymes from design to catalytic mechanism.Science China. Chemistry · 2023Review
- Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy.Nano-micro letters · 2022Article
- Iron-doped tungsten disulfide nanozyme with peroxidase-like activity for hydrogen peroxide (HScience progressArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanocatalysts with enzyme-like catalytic activities, such as oxidase mimics, are extensively used in biomedicine and environmental treatment. Searching for enzyme-like nanomaterials, clarifying the origins of catalytic activity and developing activity assessment methodologies are therefore of great significance. Here, we report that oxidase catalysis and oxygen reduction reaction (ORR) electrocatalysis can be well bridged based on their identical activity origins, which makes facile electrocatalytic ORR activity measurements intrinsically applicable to oxidase-like activity evaluations. Inspired by natural heme-copper oxidases, Cu/Fe-doped single-atom catalysts (SACs) were first synthesized and used as model catalysts. Chromogenic reactions, electrochemical voltammetric measurements and density functional theory calculations further verified the linear relationship between the oxidase-like and ORR catalytic activities of the catalysts; thus, an effective descriptor ([Formula: see text]) is proposed for rapid enzymatic catalyst evaluation. Evidence suggests that the enhanced tumour therapeutic efficacy of SACs is a result of their oxidase-like/ORR activities, which proves that numerous ORR electrocatalysts are promising candidates for oxidase mimics and tumour therapy. The synergistic catalytic effect of the biomimetic heterobinuclear Cu-Fe centres has also been thoroughly probed.
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