ArticleCNS neuroscience & therapeutics2023
Brain-clinical signatures for vagus nerve stimulation response.
Article in CNS neuroscience & therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Prognostic factors in vagus nerve stimulation for drug-resistant epilepsy. Results from a systematic review and meta-analysis of the literature.Neurosurgical review · 2026Pooled it
- Structural morphometry distinguishes vagus nerve stimulation outcomes in individuals with epilepsy.Epilepsia open · 2026Article
- A deep representation learning model to predict response to vagus nerve stimulation.Nature communications · 2026Article
- Article
- Differentiating Temporal Plus "Insula" Epilepsy From Temporal Lobe Epilepsy by Brain Networks Based on Noninvasive Examinations.CNS neuroscience & therapeutics · 2025Article
- Vagus nerve stimulation for epilepsy: A narrative review of factors predictive of response.Epilepsia · 2024Review
- Observational
- Deep Learning Approaches for Imaging-Based Automated Segmentation of Tuberous Sclerosis Complex.Journal of clinical medicine · 2024Article
- A Comprehensive Review of Emerging Trends and Innovative Therapies in Epilepsy Management.Brain sciences · 2023Review
- Brain-clinical signatures for vagus nerve stimulation response.CNS neuroscience & therapeutics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimVagus nerve stimulation (VNS) is a valuable treatment for drug-resistant epilepsy (DRE) without the indication of surgical resection. The clinical heterogeneity of DRE has limited the optimal indication of choice and diagnosis prediction. The study aimed to explore the correlations of brain-clinical signatures with the clinical phenotype and VNS responsiveness.
methodsA total of 89 DRE patients, including VNS- (n = 44) and drug-treated (n = 45) patients, were retrospectively recruited. The brain-clinical signature consisted of demographic information and brain structural deformations, which were measured using deformation-based morphometry and presented as Jacobian determinant maps. The efficacy and presurgical differences between these two cohorts were compared. Then, the potential of predicting VNS response using brain-clinical signature was investigated according to the different prognosis evaluation approaches.
resultsThe seizure reduction was higher in the VNS-treated group (42.50%) as compared to the drug-treated group (12.09%) (p = 0.11). Abnormal imaging representation, showing encephalomalacia (p
conclusionThe brain-clinical signature illustrated its clinical potential in predicting the VNS response, which might allow clinicians to personalize treatment decisions for DRE patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.