Evidence map›Paper›PMID 36415104›Full record

ReviewAmerican journal of hematology2023

Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia.

Jorge J Castillo, Christian Buske, Judith Trotman, Shayna Sarosiek, Steven P Treon

Open access · hybridAbstract readReview
In one paragraph

Review in American journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frequency and Relevance of MYD88European journal of neurology · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Zanubrutinib: past, present, and future.Blood cancer journal · 2023
    Review
  12. Review
  13. Review
  14. The performance and applied value ofAmerican journal of nuclear medicine and molecular imaging · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Jorge J CastilloBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9490-7532
Christian BuskeComprehensive Cancer Center Ulm, Institute of Experimental Cancer Research, University Hospital Ulm, Ulm, Germany.ORCID 0000-0002-9782-9012
Judith TrotmanDepartment of Haematology, Concord Repatriation General Hospital, Faculty of Medicine, University of Sydney, Concord, Australia.ORCID 0000-0001-8009-4593
Shayna SarosiekBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-0075-6735
Steven P TreonBing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-6393-6154
Harvard University · USThe University of Sydney · AUUniversity Hospital Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include indefinite duration therapy, high cost, scarcity of complete responses, and lower rates and shorter duration of response in patients with CXCR4 mutations. Herein, we review the data supporting the use of covalent BTK inhibitors, selected management issues, clinical trials with covalent BTK inhibitor combination regimens, and up-and-coming non-covalent BTK inhibitors.

Indexed as

Lymphoma, B-CellWaldenstrom MacroglobulinemiaAdenineAgammaglobulinaemia Tyrosine KinaseHumansPiperidinesProtein Kinase InhibitorsPyrazolesPyrimidinesTyrosine Kinase InhibitorsAdenineAgammaglobulinaemia Tyrosine KinasePiperidinesProtein Kinase InhibitorsPyrazolesPyrimidinesTyrosine Kinase Inhibitors

Identifiers

PMID36415104
PMCPMC10107762
OpenAlexW4309706854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.