Evidence map›Paper›PMID 36415026›Full record

ArticleMolecular nutrition & food research2023

Camel Milk Cannot Prevent the Development of Cow's Milk Allergy-A Study in Brown Norway Rats.

Natalia Zofia Maryniak, Mette Halkjaer Stage, Anne-Sofie Ravn Ballegaard, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bøgh

Abstract read
In one paragraph

Article in Molecular nutrition & food research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natalia Zofia MaryniakNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark.
Mette Halkjaer StageNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark.
Anne-Sofie Ravn BallegaardNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark.
Ana Isabel SanchoNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark.
Egon Bech HansenNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark.
Katrine Lindholm BøghNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DK-2800, Denmark.ORCID https://orcid.org/0000-0002-5266-0372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeCurrently there are no specific recommendations for the use of any particular infant formula in the prevention of cow's milk allergy (CMA). Recently, there has been an increasing interest in alternative infant formulas based on milk proteins from other sources than the cow, including milk from other mammalians such as goat, sheep, donkey, horse, and camel. Whereas these have been studied for their usability in CMA management, there are no studies of their CMA preventive capacity. Thus, the aim of this study is to evaluate whether camel milk can prevent CMA and vice versa. METHODS AND

resultsThe capacity of camel milk in preventing CMA and vice versa is evaluated in a well-established prophylactic Brown Norway rat model. IgG1, IgE, and IgA responses, allergy elicitation, intestinal and mLN gene expression, and protein uptake are analyzed. The study demonstrates that camel and cow's milk in general has an insignificant cross-preventive capacity. Yet, whereas cow's milk is shown to have a low transient capacity to prevent sensitization and clinically active camel milk allergy, camel milk does not show this effect for CMA.

conclusionsThis study suggests that due to lack of cross-tolerance camel milk cannot be used for CMA prevention.

Indexed as

MilkMilk HypersensitivityAllergensAnimalsCamelusCattleFemaleInfant FormulaMilk ProteinsRatsAllergensMilk Proteinsallergy preventionanimal modelcamel milkcow's milk allergyfood allergyinfant formula

Identifiers

PMID36415026
PMCPMC10078016

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.