ArticleCancer imaging : the official publication of the International Cancer Imaging Society2022
Shear wave elastography for differentiating parathyroid neoplasms with malignant diagnosis or uncertain malignant potential from parathyroid adenomas: initial experience.
Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 7 citations in OpenAlex.
- Shear wave elastography can improve the preoperative diagnosis of parathyroid carcinoma or atypical parathyroid tumor: initial experience.BMC medical imaging · 2026Article
- A case series of ultrasound and pathological assessment of follicular thyroid tumors: Addressing indeterminate malignancy.Medicine · 2025Article
- A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors.Frontiers in endocrinology · 2025Article
- An explainable radiomics-based machine learning model for preoperative differentiation of parathyroid carcinoma and atypical tumors on ultrasound: a retrospective diagnostic study.Frontiers in endocrinology · 2025Article
- Case report: Ultrasound misdiagnoses atypical parathyroid adenoma as malignant thyroid tumor.Frontiers in oncology · 2024Article
- Localization Strategy Prior to Radiofrequency Ablation for Primary and Secondary Hyperparathyroidism.Biomedicines · 2023Article
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9 authors at 1 institution in 1 country.
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Abstract
objectiveParathyroid carcinoma (PC) and atypical parathyroid tumor (APT) are rare parathyroid disorders carrying the risk of recurrence of varying degrees. This study aims to explore the value of 2D-shear wave elastography (SWE) in the discrimination of PC/APT among suspicious parathyroid lesions. METHODS AND MATERIALS: In this prospective study, patients with primary hyperparathyroidism and suspicious parathyroid lesions on ultrasonography (US) were recruited. All the lesions were assessed by SWE before surgery. The velocity (m/s), Young's modulus (Kpa), and elastogram of SWE were compared between pathologically proven parathyroid carcinoma or atypical parathyroid tumor (Group1) and parathyroid adenoma (Group2). All the SWE parameters were displayed at the setting of 50 or 70 kPa. Correlations between SWE and the lesion size as well as biochemical parameters were analyzed.
results36 target lesions were enrolled for analysis. The mean shear wave velocity (SWV) between the two groups was 2.4 m/s vs 1.9 m/s, respectively, while the mean Young's modulus was 11.1 kPa vs 18.2 kPa, respectively. The cut-off values are 2.35 m/s and 17.05 kPa correspondingly. The sensitivity and specificity of the selecting cut-off values were 0.56 vs 0.63 and 0.95 vs 1.0 (area under the curve [AUC]: 0.813 vs 0.852 [95% confidence interval (CI): 0.669-0.956 vs 0.720-0.983]; p < 0.001, p < 0.001; respectively). In contrast, the max SWV and Young's modulus showed a better sensitivity of 0.75 and 0.81, respectively. The "colored lesion" and "stiff rim" patterns on the elastogram are more indicated in parathyroid carcinoma and atypical parathyroid tumor, whereas the negative elastogram prevails in parathyroid adenoma. The SWV and Young's modulus of the parathyroid lesions were independent of the tumor size, but the max SWV and Young's modulus slightly correlated with serum parathyroid hormone concentration (PTH) (r = 0.398, p = 0.016; r = 0.396, p = 0.017).
conclusions2D-shear wave elastography plays a useful role in the preoperative assessment of parathyroid lesions with suspicious malignancy. The mean SWV and Young's modulus are advised as the favored diagnostic parameter with the best AUC and excellent specificities, while the max SWV and Young's modulus are more sensitive to distinguish the PC and APT compared with other parameters.
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